Minimizing Risks of Liver Transplantation With Steatotic Donor Livers by Preferred Recipient Matching
Minimizing Risks of Liver Transplantation With Steatotic Donor Livers by Preferred Recipient Matching
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DOI：
10.1097/tp.0000000000003052
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发表时间：
2020-08-01
期刊：
影响因子：
6.2
通讯作者：
Segev, Dorry L.
中科院分区：
文献类型：
--
作者：
Jackson, Kyle R.;Motter, Jennifer D.;Segev, Dorry L.
背景资料。巨大脂肪变性(脂肪变性肝脏)为30%的供体肝脏可能扩大到供体池，但经常被丢弃，因为它们与死亡和移植物丢失的风险增加有关。我们假设有某些受体表型能很好地耐受供体脂肪变性，因此最适合接受这些移植物。方法：研究方法。使用2006至2017年间移植受者科学登记处的国家登记数据，我们比较了2048名脂肪变性肝移植受者和69 394名非脂肪变性肝移植受者(
Background. Donor livers with >= 30% macrosteatosis (steatotic livers) represent a possible expansion to the donor pool, but are frequently discarded as they are associated with an increased risk of mortality and graft loss. We hypothesized that there are certain recipient phenotypes that would tolerate donor steatosis well, and are therefore best suited to receive these grafts. Methods. Using national registry data from the Scientific Registry of Transplant Recipients between 2006 and 2017, we compared 2048 liver transplant recipients of steatotic livers with 69 394 recipients of nonsteatotic (