Risks of Cardiovascular Events in Patients With Inflammatory Bowel Disease in China: A Retrospective Multicenter Cohort Study
Risks of Cardiovascular Events in Patients With Inflammatory Bowel Disease in China: A Retrospective Multicenter Cohort Study
复制标题
中国炎症性肠病患者的心血管事件风险：一项回顾性多中心队列研究
DOI：
10.1093/ibd/izab326
复制
发表时间：
2022-06-02
影响因子：
4.9
通讯作者：
Liu, Zhanju
中科院分区：
文献类型：
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作者：
Fang, Leilei;Gao, Han;Liu, Zhanju
背景
炎症性肠病（IBD）是一种以全身炎症为特征的复杂慢性疾病，可引起凝血功能异常，导致心脏事件。本研究旨在调查中国IBD患者心脏事件的发生率和风险。
方法
进行了一项回顾性队列研究，包括来自中国12家IBD中心的1，435例IBD患者。根据年龄、性别和实验室参数，将病例与来自12个医疗中心的1，588名无IBD的合格参与者进行匹配。
结果
IBD患者缺血性心脏病（包括冠心病）的发生率显著高于对照组，而右束分支传导阻滞和期前收缩的发生率显著低于对照组。IBD患者中IHD的风险增加，在18-35岁时达到峰值。女性IBD患者比男性患者更容易发生IHD。在克罗恩病（CD）患者中，外周血C反应蛋白（CRP）水平和中性粒细胞计数与IHD风险呈正相关，而血浆纤维蛋白原水平与CD和UC患者IHD风险均呈负相关。
结论
与匹配的非IBD受试者相比，IBD患者（尤其是年轻女性IBD患者）的IHD风险增加。CRP、血浆纤维蛋白原水平和外周血中性粒细胞计数可能是IBD患者发生IHD的潜在预测因素。该研究的发现对IBD患者心脏事件的管理和预防具有重要意义。
BACKGROUND
Inflammatory bowel disease (IBD) is a complex chronic disorder characterized by systemic inflammation, which may cause abnormal state of coagulation, resulting in cardiac events. This study aimed to investigate the incidences and risks of cardiac events in patients with IBD in China.
METHODS
A retrospective cohort study was performed comprising 1,435 patients with IBD from 12 IBD centers in China. Cases were matched with 1,588 eligible participants without IBD from 12 medical centers according to age, sex, and laboratory parameters.
RESULTS
Patients with IBD in China exhibited significantly higher incidences of ischemic heart disease (IHD) (coronary heart disease included) but lower frequencies of right bundle branch block and premature contraction than those of matched controls. The risk of IHD increased in patients with IBD, peaking at the age of 18-35 years. Female patients with IBD were more likely to experience IHD than male patients. C-reactive protein (CRP) levels and neutrophil count in the peripheral blood were positively related with the risk of IHD among patients with Crohn's disease (CD), whereas plasma fibrinogen levels were negatively related with the risk of IHD both in patients with CD and UC.
CONCLUSIONS
The risk of IHD is increased in patients with IBD, especially in young female patients with IBD when compared to matched non-IBD subjects. CRP and plasma fibrinogen levels and neutrophil count in the peripheral blood may be potential predictors associated with the occurrence of IHD in patients with IBD. The study's findings have significant implications for the management and prevention of cardiac events in patients with IBD.