Step-up fecal microbiota transplantation (FMT) strategy.
Step-up fecal microbiota transplantation (FMT) strategy.
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DOI：
10.1080/19490976.2016.1151608
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发表时间：
2016-07-03
期刊：
影响因子：
12.2
通讯作者：
Zhang F
中科院分区：
文献类型：
--
作者：
Cui B;Li P;Xu L;Peng Z;Xiang J;He Z;Zhang T;Ji G;Nie Y;Wu K;Fan D;Zhang F
肠道生态失调是炎症性肠病（IBD）的特征，并被认为在IBD的发病机制中起作用。粪便微生物群移植（FMT）是恢复肠道微生物多样性的有效策略，已被报道在IBD中具有潜在的治疗价值。我们最近的研究报告了一种整体综合疗法，称为“逐步FMT策略”，这是有益的治疗激素依赖性IBD患者。该策略包括计划的FMT联合类固醇、抗TNF-α抗体治疗或肠内营养。在此，我们将详细阐述这一策略，详细介绍“加强FMT策略”的概念、潜在适应症、方法学和安全性。
Gut dysbiosis is a characteristic of inflammatory bowel disease (IBD) and is believed to play a role in the pathogenesis of IBD. Fecal microbiota transplantation (FMT) is an effective strategy to restore intestinal microbial diversity and has been reported to have a potential therapeutic value in IBD. Our recent study reported a holistic integrative therapy called “step-up FMT strategy,” which was beneficial in treating steroid-dependent IBD patients. This strategy consists of scheduled FMTs combined with steroids, anti-TNF-α antibody treatment or enteral nutrition. Herein, we will elaborate the strategy thoroughly, introducing the concept, potential indication, methodology, and safety of “step-up FMT strategy” in detail.