Modular ligand variation in calcium bisimidazoline complexes: effects on ligand redistribution and hydroamination catalysis.
Modular ligand variation in calcium bisimidazoline complexes: effects on ligand redistribution and hydroamination catalysis.
复制标题
DOI：
10.1039/c1dt10732a
复制
发表时间：
2011-07
影响因子：
4
通讯作者：
James S. Wixey;Benjamin D. Ward
中科院分区：
文献类型：
--
作者：
James S. Wixey;Benjamin D. Ward
研究了手性双咪唑啉配体负载的一系列钙配合物在氨基烯烃分子内催化氢胺化/环化反应中的作用。与目前有关钙的文献研究相比，配合物[Ca(R- bim){N(SiMe(3))(2)}(THF)] (R = 4- c (6)H(4)Me, 5a, 4- c (6)H（4)F， 5b和(t)Bu, 5c）具有竞争性的对映选择性（高达12%）。通过模块化合成途径，双咪唑类药物提供了比类似双恶唑啉配体更大的结构差异。
A series of calcium complexes supported by chiral bisimidazoline ligands have been studied in the catalytic intramolecular hydroamination/cyclisation of amino-olefins. The complexes [Ca(R-BIM){N(SiMe(3))(2)}(THF)] (R = 4-C(6)H(4)Me, 5a, 4-C(6)H(4)F, 5b and (t)Bu, 5c) have given competitive enantioselectivities (up to 12%) when compared to current literature studies involving calcium. Bisimidazolines offer a significant advance over similar bisoxazoline ligands, by allowing a greater structural variance through a modular synthetic pathway.