The DNA damage response: Ten years after
The DNA damage response: Ten years after
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DOI：
10.1016/j.molcel.2007.11.015
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发表时间：
2007-12-14
期刊：
影响因子：
16
通讯作者：
Elledge, Stephen J.
中科院分区：
文献类型：
--
作者：
Harper, J. Wade;Elledge, Stephen J.
DNA损伤反应（DDR）通过传感器、换能器和效应器的作用，协调DNA损伤的适当修复和DNA复制问题的解决，协调这些过程与正在进行的细胞生理学。在过去的十年中，我们见证了对DNA损伤传感，信号传导以及DDR网络用于执行DNA损伤响应的蛋白质磷酸化和泛素途径之间复杂相互作用的理解的爆炸。这些发现对衰老和癌症有重要意义。
The DNA damage response (DDR), through the action of sensors, transducers, and effectors, orchestrates the appropriate repair of DNA damage and resolution of DNA replication problems, coordinating these processes with ongoing cellular physiology. In the past decade, we have witnessed an explosion in understanding of DNA damage sensing, signaling, and the complex interplay between protein phosphorylation and the ubiquitin pathway employed by the DDR network to execute the response to DNA damage. These findings have important implications for aging and cancer.