Frequency-dependent activation pattern in the rat hippocampus, a simultaneous electrophysiological and fMRI study
Frequency-dependent activation pattern in the rat hippocampus, a simultaneous electrophysiological and fMRI study
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DOI：
10.1016/j.neuroimage.2007.07.022
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发表时间：
2007-10-15
期刊：
影响因子：
5.7
通讯作者：
Frey, Sabine
中科院分区：
文献类型：
--
作者：
Angenstein, Frank;Kammerer, Elena;Frey, Sabine
通过齿状回电生理记录和功能磁共振成像（fMRI）同时分析电穿孔通路刺激期间频率依赖性海马激活。低频刺激（2.5 Hz）下的脉冲串不影响齿状回刺激串内的电生理反应，也未触发可检测到的BOLD反应。增加的刺激频率（5.0-20 Hz）产生BOLD响应的大致线性增强。齿状回内的BOLD信号与刺激模式的相关性比与颗粒细胞产生的动作电位的相关性更密切。然而，BOLD信号的强烈影响，由重复刺激列车激活的额外的本地信号处理。fMRI显示海马的频率特异性空间激活模式;在5 Hz刺激期间齿状回的空间限制激活，在10 Hz下整个海马和下托的激活以及在20 Hz刺激期间对侧海马的激活。(c)2007爱思唯尔公司All rights reserved.
Frequency-dependent hippocampal activation during electrical perforant pathway stimulation was analyzed simultaneously by electrophysiological recordings in dentate gyrus and functional magnetic resonance imaging (fMRI). Pulse trains at low-frequency stimulation (2.5 Hz) did not influence electrophysiological responses within stimulation trains in the dentate gyrus and triggered no detectable BOLD responses. Increased stimulation frequencies (5.0-20 Hz) generated a roughly linear enhancement of the BOLD response. The BOLD signal within the dentate gyrus correlated more closely with stimulus pattern than with generated action potentials of the granular cells. However, the BOLD signal was strongly influenced by additional local signal processing activated by repetitive stimulus trains. fMRI visualized a frequency-specific spatial activation pattern of the hippocampus; spatially restricted activation in the dentate gyrus during 5-Hz stimulation, activation of the entire hippocampus and subiculum at 10 Hz and activation of the contralateral hippocampus during 20-Hz stimulation. (c) 2007 Elsevier Inc. All rights reserved.