A DOUBLE-BLIND COMPARISON OF PAROXETINE AND PLACEBO IN THE TREATMENT OF DEPRESSED OUTPATIENTS
A DOUBLE-BLIND COMPARISON OF PAROXETINE AND PLACEBO IN THE TREATMENT OF DEPRESSED OUTPATIENTS
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DOI：
10.1097/00004850-199206004-00006
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发表时间：
1992-06-01
影响因子：
2.6
通讯作者：
CLAGHORN, J
中科院分区：
文献类型：
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作者：
CLAGHORN, J
一项双盲、安慰剂对照、随机试验被用来比较帕罗西汀对无躁狂症的中重度抑郁症患者的疗效和耐受性。与安慰剂相比，帕罗西汀被发现是一种有效的抗抑郁药物。在大多数疗效指标中，益处出现在治疗两周后，但睡眠在一周后得到改善。服用帕罗西汀的患者比服用安慰剂的患者抱怨更多的不良反应；他们主要是胃肠道反应，恶心是最常见的报道。
A double-blind, placebo-controlled, randomized trial was carried out to compare the efficacy and tolerability of paroxetine in outpatients with moderate to moderately severe depression without mania. Paroxetine was found to be an effective antidepressant drug when compared to placebo. For most of the measures of efficacy the benefit appeared after two weeks of therapy, but sleep was improved after one week. Patients taking paroxetine complained of more adverse effects than those on placebo; they were mainly gastrointestinal with nausea the most commonly reported.