Periportal fibrosis, liver and spleen sizes among S. mansoni mono or co-infected individuals with human immunodeficiency virus-1 in fishing villages along Lake Victoria shores, North-Western, Tanzania.
Periportal fibrosis, liver and spleen sizes among S. mansoni mono or co-infected individuals with human immunodeficiency virus-1 in fishing villages along Lake Victoria shores, North-Western, Tanzania.
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DOI：
10.1186/s13071-015-0876-4
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发表时间：
2015-05-07
影响因子：
3.2
通讯作者：
Nuwaha F
中科院分区：
文献类型：
--
作者：
Mazigo HD;Dunne DW;Morona D;Lutufyo TE;Kinung'hi SM;Kaatano G;Nuwaha F
对S.曼氏菌感染涉及对寄生虫卵的慢性炎症反应，其可与特征性门脉周围纤维化（PPF）和进展为严重的肝脾疾病相关。探讨HIV-1合并感染及CD 4+细胞数对慢性S.曼索尼人不知道。为了了解HIV-1合并感染对这些发病率的影响，我们检测了S。mansoni超声波检测的发病率与HIV-1感染和CD 4+细胞计数有关，以及存在这两种感染的渔业社区的其他因素。在坦桑尼亚西北部对1，671名（年龄21-55岁）个体进行横断面研究期间进行了超声检查。采集血样进行HIV-1筛查和CD 4+细胞定量。对一份粪便样本进行了S。使用加藤-卡茨技术的曼氏菌卵调查问卷被用来收集社会人口经济信息。HIV-1感染者和非感染者PPF（C-F级）的患病率分别为13.79%和15.01%（P = 0.72）。男性（P< 0.001）、年龄组21-30岁（P< 0.028）、居住时间11-20年（P< 0.01）和≥21年（P< 0.01）与PPF有关。感染曼氏症的人。HIV-1/S患者左肝叶的高度校正测量值显著更大。mansoni与S.仅感染曼氏菌的个体（t =-2.0702，P< 0.039）。身高校正后的左肝叶和左脾测量值的预测因子为年龄、男性、疟疾感染、渔业、居住村庄和S。曼氏感染。在考虑这些因素后，HIV-1感染和CD 4+细胞计数均不能预测PPF、肝脾肿大、肝脏或脾脏的测量结果。在合并感染的个体中，左肝叶的高度调整超声测量值与CD 4+细胞计数无关（r =-0.16，P = 0.084）。S.研究人群中普遍存在曼氏相关PPF、肝脏和脾脏肿大。S.曼氏菌感染与肝、脾肿大有关。在两种HIV-1/S中观察到的PPF等级相似。mansoni共感染组和单纯感染S. mansoni没有证据表明HIV-1感染或CD 4+细胞计数与这些S。曼氏病
The pathogenesis of S. mansoni infection involves chronic inflammatory responses to parasite eggs which can be associated with a characteristic periportal fibrosis (PPF) and the progression to severe hepatosplenic disease. The effects of HIV-1 co-infection and the influence of CD4+ cell numbers on these clinical manifestations of chronic S. mansoni are not known. To understand the effects of HIV-1 co-infection on these morbidities, we examined S. mansoni ultrasound-detectable morbidities in relation to HIV-1 infection and CD4+ cell counts, and other factors in fishing communities where the two infections are present. Ultrasonographical examination was conducted during a cross-sectional study of 1,671 (aged 21–55 years) individuals in North-Western Tanzania. Blood samples were obtained for HIV-1 screening and CD4+ cell quantification. A single stool sample was examined for S. mansoni eggs using the Kato-Katz technique. A questionnaire was used to collect socio-demographic-economic information. The prevalence of PPF (grade C-F) was 13.79% and 15.01% for the HIV-1 infected and non-infected individuals (P = 0.72). Male gender (P< 0.001), age group 21–30 years (P< 0.028) and, residential time of 11–20 (P< 0.01) and ≥21 years (P< 0.01) were associated with PPF in S. mansoni infected individuals. The height-adjusted measurements of the left liver lobe were significantly larger in HIV-1/S. mansoni co-infected compared to S. mansoni only-infected individuals (t = −2.0702, P< 0.039). Predictors of the height-adjusted measurements of the left liver lobe and spleen were age, male gender, malaria infection, fishing occupation, village of residence and heavy intensity of S. mansoni infection. After accounting for these factors, neither HIV-1 infection nor CD4+ cell counts predicted PPF, hepatosplenomegaly, measurements of the liver or spleen. Height-adjusted ultrasound measurements of the left liver lobe did not correlate with the CD4+ cells counts in co-infected individuals (r = −0.16, P = 0.084). S. mansoni-related PPF, liver and spleen enlargement are prevalent in the study population. The intensity of S. mansoni infection was associated with the enlargement of liver, spleen and hepatosplenomegaly. The PPF grades observed were similar in both HIV-1/S. mansoni co-infected and in those only infected with S. mansoni. There was no evidence that HIV-1 infection or CD4+ cells counts were associated with these S. mansoni morbidities.
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DOI：
10.4269/ajtmh.1968.17.38
发表时间：
1968-01-01
影响因子：
3.3
作者：
CHEEVER, AW
通讯作者：
CHEEVER, AW
影响因子：
2
作者：
El Scheich, Tarik;Hofer, L.;Richter, J.
通讯作者：
Richter, J.
DOI：
10.4269/ajtmh.1995.53.660
发表时间：
1995-12-01
影响因子：
3.3
作者：
Guyatt, H;Gryseels, B;Tanner, M
通讯作者：
Tanner, M
DOI：
10.4269/ajtmh.1997.56.515
发表时间：
1997-05-01
影响因子：
3.3
作者：
Karanja, DMS;Colley, DG;Secor, WE
通讯作者：
Secor, WE
DOI：
10.1016/0035-9203(81)90012-2
发表时间：
1981-01-01
影响因子：
2.2
作者：
DOENHOFF, MJ;PEARSON, S;HASSOUNAH, O
通讯作者：
HASSOUNAH, O