Tumor size predicts synchronous metastatic renal cell carcinoma: Implications for surveillance of small renal masses
Tumor size predicts synchronous metastatic renal cell carcinoma: Implications for surveillance of small renal masses
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DOI：
10.1016/j.juro.2007.01.029
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发表时间：
2007-05-01
影响因子：
6.6
通讯作者：
Uzzo, Robert G.
中科院分区：
文献类型：
--
作者：
Kunkle, David A.;Crispen, Paul L.;Uzzo, Robert G.
目的：积极监测偶发性肾脏小肿块与放射学生长缓慢和转移进展风险低相关。在缺乏组织学资料的情况下，放射学肿瘤大小是考虑主动监测时唯一可用的预后指标。为了更好地定义肿瘤大小和转移潜力的小肾肿块之间的关系，我们调查是否放射学肿瘤大小预测存在同步转移在renal cell carcinoma.Materials和Methods：我们回顾了我们的机构肿瘤登记，以确定散发性病理证实的肾细胞癌治疗在8年的时间。我们分析了原发肿瘤的大小和活检证实的同时转移性疾病的存在。所有的N+M0和非病理证实的M+疾病被排除在analysis.Results：我们比较了110例肾细胞癌活检证实同步转移性疾病在介绍250对照临床局部肾细胞癌。与同步转移相关的肿瘤明显大于局限性病变（中位数8.0 cm [范围2.2 - 20.0] vs 4.5 cm [范围0.3 - 17.5]，p
Purpose: Active surveillance of small incidental renal masses is associated with slow radiographic growth and a low risk of metastatic progression. Radiographic tumor size, in the absence of histological data, is the only prognostic indicator available when considering active surveillance. To better define the relationship between tumor size and the metastatic potential of small renal masses, we investigated whether radiographic tumor size predicts for the presence of synchronous metastases in renal cell carcinoma.Materials and Methods: We reviewed our institutional tumor registry to identify sporadic pathologically verified renal cell carcinoma treated during an 8-year period. We analyzed data regarding primary tumor size and the presence of biopsy proven synchronous metastatic disease at presentation. All N+M0 and nonpathologically confirmed M+ disease was excluded from analysis.Results: We compared 110 cases of renal cell carcinoma with biopsy proven synchronous metastatic disease at presentation to 250 controls with clinically localized renal cell carcinoma. Tumors associated with synchronous metastasis were significantly larger than localized lesions (median 8.0 cm [range 2.2 to 20.0] vs 4.5 cm [range 0.3 to 17.5], p