A mass spectrometric insight into the origins of benign gynecological disorders.
A mass spectrometric insight into the origins of benign gynecological disorders.
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DOI：
10.1002/mas.21484
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发表时间：
2017-05
影响因子：
6.6
通讯作者：
Huiliang Yang;W. Lau;Bonnie Lau;Yu Xuan;Shengtao Zhou;Linjie Zhao;Zhongyue Luo;Qiao Lin;Ning Ren;Xia Zhao;Yuquan Wei
中科院分区：
文献类型：
--
作者：
Huiliang Yang;W. Lau;Bonnie Lau;Yu Xuan;Shengtao Zhou;Linjie Zhao;Zhongyue Luo;Qiao Lin;Ning Ren;Xia Zhao;Yuquan Wei
质谱（MS）的应用正在迅速扩大，并涵盖分子和细胞生物学。MS有助于分析体内整体分子变化，识别可能改善各种病理学诊断和治疗的潜在生物标志物。MS为医学研究增加了新的维度。开创性的妇科医生现在研究女性生殖病理学的分子机制与MS为基础的工具。虽然良性妇科疾病包括子宫内膜异位症、子宫腺肌病、平滑肌瘤和多囊卵巢综合征（PCOS）的死亡率较低，但它们会引起显著的身体、精神和社会损害。此外，一些良性疾病不幸地与恶性肿瘤相关。基于MS的技术可以检测以前良性蛋白质组和代谢组的恶性变化，具有速度，灵敏度和特异性的明显优势。我们目前使用的MS在蛋白质组学和代谢组学，并总结了目前的理解有关女性生殖解剖的分子途径。通过基于MS的技术突出新的蛋白质和代谢物生物标志物的发现，我们强调这些技术在诊断和管理良性妇科疾病的临床应用。© 2015威利期刊公司.质量标准修订版36：450-470，2017。
Applications of mass spectrometry (MS) are rapidly expanding and encompass molecular and cellular biology. MS aids in the analysis of in vivo global molecular alterations, identifying potential biomarkers which may improve diagnosis and treatment of various pathologies. MS has added new dimensionality to medical research. Pioneering gynecologists now study molecular mechanisms underlying female reproductive pathology with MS-based tools. Although benign gynecologic disorders including endometriosis, adenomyosis, leiomyoma, and polycystic ovarian syndrome (PCOS) carry low mortality rates, they cause significant physical, mental, and social detriments. Additionally, some benign disorders are unfortunately associated with malignancies. MS-based technology can detect malignant changes in formerly benign proteomes and metabolomes with distinct advantages of speed, sensitivity, and specificity. We present the use of MS in proteomics and metabolomics, and summarize the current understanding of the molecular pathways concerning female reproductive anatomy. Highlight discoveries of novel protein and metabolite biomarkers via MS-based technology, we underscore the clinical application of these techniques in the diagnosis and management of benign gynecological disorders. © 2015 Wiley Periodicals, Inc. Mass Spec Rev 36:450-470, 2017.