Effects of sex steroids on plasma total homocysteine levels: A study in transsexual males and females
Effects of sex steroids on plasma total homocysteine levels: A study in transsexual males and females
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DOI：
10.1210/jc.83.2.550
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发表时间：
1998-02-01
影响因子：
5.8
通讯作者：
Stehouwer, CDA
中科院分区：
文献类型：
--
作者：
Giltay, EJ;Hoogeveen, EK;Stehouwer, CDA
Plasma total homocysteine (tHcy) levels are higher in men vs. premenopausal women, but it is not known whether this difference is related to sex steroids. The effects of cross-sex hormone administration on plasma tHcy levels were therefore investigated.Plasma tHcy levels were measured at baseline and after 4 months of treatment in 17 male-to-female (M-->F) transsexuals treated with ethinyl estradiol (100 mu g/day), in combination with the antiandrogen, cyproterone acetate (100 mg/day), and in 17 female-to-male (F-->M) transsexuals treated with testosterone esters (250 mg/2 weeks, im).In M-->F transsexuals, the plasma tHcy level decreased from geometric mean 8.2 mu mol/L to 5.7 mu mol/L (P < 0.001); and in F-->M transsexuals, it increased from 7.7 mu mol/L to 9.0 mu mol/L (P = 0.005). In M-->F transsexuals, changes in serum sex hormone-binding globulin levels correlated negatively, and changes in plasma creatinine and albumin levels correlated positively, with changes in plasma tHcy levels. In F-->M transsexuals, changes in serum 17 beta-estradiol levels correlated negatively, and changes in plasma creatinine levels correlated positively, with changes in plasma tHcy levels.We conclude that tHcy levels decrease after estrogen + antiandrogen administration to male (transsexual) subjects, and levels increase after androgen administration to female (transsexual) subjects. These changes may be both primary and secondary to the anabolic/catabolic effects, as reflected by changes of creatinine and albumin levels after cross-sex hormone administration.
