Spontaneous paroxysmal circling behavior in the ci2 rat mutant:: Epilepsy with rotational seizures or hyperkinetic movement disorder?
Spontaneous paroxysmal circling behavior in the ci2 rat mutant:: Epilepsy with rotational seizures or hyperkinetic movement disorder?
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DOI：
10.1006/exnr.2001.7802
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发表时间：
2001-12-01
影响因子：
5.3
通讯作者：
Löscher, W
中科院分区：
文献类型：
--
作者：
Lindemann, S;Lessenich, A;Löscher, W
绕圈、转动、旋转、自旋、轮转和草书运动亢进都是同义词，用于描述动物沿圆周方向的主动运动。转圈行为可以由单侧电和化学刺激或不同大脑部位的损伤引起，但也可以在全身给药后或在正常动物或突变啮齿动物中自发发生。在人类中，刻板的身体旋转可以作为全身性和局灶性癫痫的独特实体而发生，并且可能是由于纹状体的参与所致。我们之前描述了一种Lewis大鼠突变体（ci2），其行为表型的特征是侧化转圈、多动、角弓反张和共济失调。在这些老鼠身上，转圈是分阶段发生的，或者是自发地或对压力做出反应而爆发的。神经化学。数据表明ci2突变体的循环行为与纹状体多巴胺能活性的异常不对称有关。由于与旋转性癫痫的相似性，我们使用视频和脑电图记录来研究 ci2 突变大鼠的旋转行为是否是部分性或全身性癫痫的结果。使用癫痫 WAG/Rij 大鼠进行比较。在没有任何压力或干扰的情况下对 ci2 大鼠进行的视频监测表明，在主动觉醒期间，转圈发生在阵发性爆发中，但在被动觉醒或睡眠期间则不会。转圈前后没有任何惊厥性运动性癫痫发作，并且与脑电图中的癫痫样异常无关，而 WAG/Rij 大鼠在被动清醒和睡眠期间表现出肌阵挛性癫痫发作和癫痫性棘波放电。由于转圈与活跃觉醒之间存在关联，ci2 大鼠在黑暗（活跃）阶段比亮（休息）阶段表现出更多的旋转。通过将大鼠转移到新的环境诱导或强化的转圈行为，增加亮阶段的主动觉醒。大多数 ci2 大鼠在绕圈过程中表现出一致的侧向偏好，但一些大鼠在一次训练和另一次训练中改变了它们的偏好。数据表明，ci2 大鼠的自发阵发性转圈行为不是癫痫的结果，而是反映了伴有脑功能异常侧化的多动性运动障碍。 (C) 2001 年爱思唯尔科学。
Circling, turning, rotating, spinning, wheeling, and cursive hyperkinesia are all synonymous terms used to describe the active movement of an animal in a circular direction. Circling behavior can be evoked by unilateral electrical and chemical stimulation or lesions of various brain sites, but can also occur after systemic drug administration or spontaneously in normal animals or mutant rodents. In humans, stereotypic body rotation can occur as a distinctive entity of generalized and focal epilepsy, and may be due to involvement of the striatum. We have previously described a Lewis rat mutant (ci2) with a behavioral phenotype characterized by lateralized circling, hyperactivity, opisthotonus, and ataxia. In these rats, circling occurs in phases or bursts either spontaneously or in response to stress. Neurochemical. data indicate that the circling behavior of the ci2 mutants is related to an abnormal asymmetry in dopaminergic activity in the striatum. Because of the similarities to rotational epilepsy, we used video and electroencephalographic recordings to study whether the rotational behavior of the ci2 mutant rat is a result of a partial or generalized epilepsy. Epileptic WAG/Rij rats were used for comparison. Video monitoring of ci2 rats in the absence of any stress or disturbance showed that circling occurs in paroxysmal bursts during active wakefulness, but not during passive wakefulness or sleep. Circling was not preceded or followed by any convulsive motor seizures and was not associated with epileptiform abnormalities in the electroencephalogram, whereas WAG/Rij rats exhibited myoclonic seizures and epileptic spike-wave discharges during passive wakefulness and sleep. As a result of the association of circling with active wakefulness, ci2 rats exhibited many more rotations during the dark (active) phase compared with the light (rest) period. Increase in active wakefulness during the light phase by transfer of the rats to a new environment induced or intensified circling behavior. Most ci2 rats showed a consistent lateral preference during circling, but some rats changed their preference from one session to another. The data indicate that spontaneous paroxysmal circling behavior in the ci2 rat is not a consequence of epilepsy but reflects a hyperkinetic movement disorder with abnormal lateralization of brain function. (C) 2001 Elsevier Science.