Gastrointestinal involvement in Henoch-Schonlein purpura
Gastrointestinal involvement in Henoch-Schonlein purpura
复制标题
过敏性紫癜的胃肠道受累
DOI：
10.1080/00365520802101861
复制
发表时间：
2008-01-01
影响因子：
1.9
通讯作者：
Huang, Xinglan
中科院分区：
文献类型：
--
作者：
Zhang, Yan;Huang, Xinglan
客观的。分析成年过敏性紫癜（HSP）患者的胃肠道表现，包括临床和内镜特征。材料和方法。纳入的患者为 1995 年 1 月至 2006 年 1 月期间入院的最终诊断为 HSP 的患者。对他们的医疗记录，包括临床表现、实验室数据、内窥镜检查和病理报告进行回顾性审查。结果。其中包括一百一十五名患者。 90例（78.2%）患者出现胃肠道症状，其中腹痛最为常见。 54 名患者接受了胃镜检查，24 名患者接受了结肠镜检查。内镜下病变包括粘膜红斑、水肿、多发不规则溃疡和结节性改变。在上消化道中，十二指肠的第二部分是最常受累的区域，也是发生最严重病变的地方。在下消化道中，直肠是最常受累的区域，但最严重的病变发生在回肠末端。结论。 HSP可能表现为急腹症，而无典型的皮肤表现，胃镜和结肠镜检查有助于这些患者HSP的早期诊断。典型的内镜检查结果包括弥漫性粘膜水肿、红斑、瘀点或多发不规则溃疡，特别是在十二指肠第二部分或回肠末端。
Objective. To analyse the gastrointestinal manifestation of Henoch-Schonlein purpura (HSP) in adult patients, including clinical and endoscopic features. Material and methods. Patients with a final diagnosis of HSP admitted from January 1995 to January 2006 were included. Their medical records, including clinical presentation, laboratory data, endoscopy and pathology reports, were reviewed retrospectively. Results. One-hundred-and-fifteen patients were included. Gastrointestinal symptoms occurred in 90 patients (78.2%), with abdominal pain the most common symptom. Fifty-four patients underwent gastroscopy, while 24 underwent colonoscopy. The endoscopic lesions included mucosal erythema, oedema, multiple irregular ulcers and nodular changes. In the upper GI tract, the second portion of the duodenum was the most frequently involved area and is where the most severe lesions occur. In the lower GI tract, the rectum was the most frequently involved area, but the most severe lesions were found in the terminal ileum. Conclusions. HSP may present with acute abdomen without typical skin manifestations, and gastroscopy and colonoscopy can be helpful in the early diagnosis of HSP in these patients. Typical endoscopic findings include diffuse mucosal oedema, erythema, petechia or multiple irregular ulcers, especially in the second portion of the duodenum or in the terminal ileum.