Various ARID1A expression patterns and their clinical significance in gastric cancers
Various ARID1A expression patterns and their clinical significance in gastric cancers
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DOI：
10.1016/j.humpath.2015.10.008
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发表时间：
2016-03-01
期刊：
影响因子：
3.3
通讯作者：
Lee, Dakeun
中科院分区：
文献类型：
--
作者：
Kim, Young-Bae;Ham, In-Hye;Lee, Dakeun
富含AT的相互作用结构域1A（ARID 1A）在胃癌中经常发生突变，ARID 1A表达的缺失被认为是各种癌症的不良预后因素。然而，在实践中，ARID 1A表现出各种各样的表达模式，我们对其意义的理解是有限的。我们使用350例胃癌的全组织块进行了ARID 1A、MLH 1和pS 6的免疫组织化学，并将ARID 1A表达分类如下：保留（63.7%）、减少（17.7%）、完全丢失（14.9%）和部分丢失（3.7%）。完全/部分丢失在低分化组织学中更常见（P < .001），ARID 1A减少或完全丢失在MLH 1丢失的病例中更常见（P < .001）。与ARID 1A保留组相比，ARID 1A减少组的无病生存期（DFS; P = 0.254）和总生存期（OS; P = 0.377）仅略差，而完全丧失组的DFS（风险比[HR]，1.732; P = 0.015）和OS（HR，1.751; P = 0.013）显著更差。部分丢失组的DFS（BR，2.672; P = .005）和OS（HR，2.531; P = .002）也更差。在ARID 1A表达模式改变的组中，pS 6的高表达更常见（P
AT-rich interactive domain 1A (ARID1A) is frequently mutated in gastric cancers, and loss of ARID1A expression is considered a poor prognostic factor in various cancers. However, in practice, ARID1A shows various expression patterns, and our understanding of its significance is limited. We performed immunohistochemistry for ARID1A, MLH1, and pS6 using whole tissue blocks of 350 gastric cancers and classified the ARID1A expression as follows: retained (63.7%), reduced (17.7%), complete loss (14.9%), and partial loss (3.7%). Complete/partial loss was more common in poorly differentiated histology (P < .001), and reduced or complete loss of ARID1A was frequent in cases with MLH1 loss (P < .001). The ARID1A-reduced group showed only slightly inferior disease-free survival (DFS; P = .254) and overall survival (OS; P = .377) compared to those of the ARID1A-retained group, whereas the group with complete loss showed significantly worse DFS (hazard ratio [HR], 1.732; P = .015) and OS (HR, 1.751; P = .013). Worse DFS (BR, 2.672; P = .005) and OS (HR, 2.531; P = .002) were also noted in the group with partial loss. High expression of pS6 was observed more frequently in groups showing altered ARID1A expression patterns (P