CIGARETTE-SMOKING AND ALCOHOL-CONSUMPTION IN THE ETIOLOGY OF UTERINE CERVICAL-CANCER
CIGARETTE-SMOKING AND ALCOHOL-CONSUMPTION IN THE ETIOLOGY OF UTERINE CERVICAL-CANCER
复制标题
DOI：
10.1093/ije/18.3.533
复制
发表时间：
1989-09-01
影响因子：
7.7
通讯作者：
CHANG, JC
中科院分区：
文献类型：
--
作者：
LICCIARDONE, JC;WILKINS, JR;CHANG, JC
A case-control study of uterine cervical cancer was conducted using 331 cases and 993 age-matched controls identified through the Missouri [USA] Cancer Registry during 1984-1986. Patients with smoking- or alcohol-related cancers were excluded from the control series. Logistic regression was used to compute odds ratios (ORs) and 95% confidence intervals (CIs) after adjustment for age, cigarette smoking, alcohol consumption, and stage at diagnosis. A dose-response relation was observed between intensity of cigarette smoking and invasive cervical cancer, with light and heavy smokers having elevated risk (OR = 2.2, 95% CI = 1.4-3.6 and OR = 3.9, 95% CI = 2.7-5.6, respectively). Former smokers had less elevated risk (OR = 1.7, 95% CI = 1.0-2.9), a finding consistent with a greater effect of tobacco smoke on late-stage carcinogenesis. Similar results were obtained in age- and control site-specific analyses. Further, the age-specific data suggested a dose-response relation between duration of smoking and invasive cervical cancer. An association between alcohol consumption and invasive cervical cancer was not observed.
