A CASE-CONTROL INVESTIGATION OF PERINATAL RISK-FACTORS FOR CHILDHOOD IDDM IN NORTHERN-IRELAND AND SCOTLAND
A CASE-CONTROL INVESTIGATION OF PERINATAL RISK-FACTORS FOR CHILDHOOD IDDM IN NORTHERN-IRELAND AND SCOTLAND
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DOI：
10.2337/diacare.17.5.376
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发表时间：
1994-05-01
期刊：
影响因子：
16.2
通讯作者：
HADDEN, DR
中科院分区：
文献类型：
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作者：
PATTERSON, CC;WAUGH, NR;HADDEN, DR
目的 - 确定儿童胰岛素依赖型糖尿病 (IDDM) 的围产期危险因素，并确定它们在早发型和晚发型疾病之间是否存在差异。 研究设计和方法 - 我们从人口登记册中选择了北爱尔兰的 258 名糖尿病儿童和苏格兰的 271 名糖尿病儿童。对于每个糖尿病儿童，从同一人群中抽取五名匹配的对照受试者。所有围产期数据均在出生时常规记录。根据父母年龄、社会阶层、母乳喂养、剥夺措施和其他围产期变量估计优势比 (OR)。 结果 - 苏格兰数据表明，高龄母亲所生子女的风险增加（OR = 2.43，相对于 35 岁以上母亲的 95% 置信区间 [CI] 1.49-3.97）
OBJECTIVE - To identify perinatal risk factors for childhood insulin-dependent diabetes mellitus (IDDM) and determine if they differ between early-onset and late-onset disease.RESEARCH DESIGN AND METHODS - We selected 258 diabetic children in Northern Ireland and 271 diabetic children in Scotland from population-based registers. For each diabetic child, five matched control subjects were drawn from the same population. All perinatal data were recorded routinely at birth. Odds ratios (ORs) were estimated for parental age, social class, breast-feeding, deprivation measures, and other perinatal variables.RESULTS - Scottish data indicated an increased risk among children born to older mothers (OR = 2.43, 95% confidence interval [CI] 1.49-3.97 for mothers greater than or equal to 35 years of age relative to those