Expression, purification, and crystallization of Toll/interleukin-1 receptor (TIR) domains.
Expression, purification, and crystallization of Toll/interleukin-1 receptor (TIR) domains.
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DOI：
10.1007/978-1-59745-541-1_6
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发表时间：
2009
影响因子：
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通讯作者：
X. Tao;L. Tong
中科院分区：
文献类型：
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作者：
X. Tao;L. Tong
toll样受体（TLRs）和白细胞介素-1受体（IL-1R）在宿主抗微生物感染的先天免疫应答中起着至关重要的作用。这些受体共享一个保守的细胞质结构域，即Toll/白细胞介素-1受体（TIR）结构域，这是通过这些受体传递信号所必需的。关于TIR结构域的结构信息对于理解这些受体信号转导的分子基础至关重要。
Toll-like receptors (TLRs) and interleukin-1 receptor (IL-1R) play crucial roles in host innate immune response against microbial infections. These receptors share a conserved cytoplasmic domain, the Toll/interleukin-1 receptor (TIR) domain, which is required for signaling through these receptors. Structural information on the TIR domains will be essential for understanding the molecular basis for signal transduction by these receptors.