High Level of Plasma EGFL6 Is Associated with Clinicopathological Characteristics in Patients with Oral Squamous Cell Carcinoma.
High Level of Plasma EGFL6 Is Associated with Clinicopathological Characteristics in Patients with Oral Squamous Cell Carcinoma.
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DOI：
10.7150/ijms.18555
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发表时间：
2017
影响因子：
3.6
通讯作者：
Chou YE
中科院分区：
文献类型：
--
作者：
Chuang CY;Chen MK;Hsieh MJ;Yeh CM;Lin CW;Yang WE;Yang SF;Chou YE
EGF样结构域6 （EGFL6）是一种促进内皮细胞迁移和血管生成的分泌蛋白，是表皮生长因子（EGF）重复蛋白超家族的成员。本研究旨在探讨口腔鳞状细胞癌（OSCC）患者的临床病理特征与血浆EGFL6水平的关系。我们使用商业酶联免疫吸附法测量了392例OSCC患者的血浆EGFL6水平。我们还分析了来自癌症基因组图谱（TCGA）数据集的328例OSCC患者的EGFL6 mRNA水平。结果显示，OSCC患者血浆EGFL6水平显著高于健康对照组（p < 0.001）。在TCGA生物信息学数据库中也观察到类似的结果。此外，晚期T状态（p= 0.002）、远处转移（p= 0.001）和TNM分期较高（p=0.033）的患者血浆EGFL6水平显著升高。总之，我们的研究结果表明血浆EGFL6水平可能有助于评估疾病进展，特别是OSCC患者的晚期T状态和较高的TNM阶段。
EGF-like domain 6 (EGFL6), a member of the epidermal growth factor (EGF) repeat protein superfamily, is a secreted protein that promotes endothelial cell migration and angiogenesis. The current study investigated the association between the clinicopathological characteristics and plasma level of EGFL6 in patients with oral squamous cell carcinoma (OSCC). We measured the plasma EGFL6 levels of 392 OSCC patients by using a commercial enzyme-linked immunosorbent assay. We also analyzed EGFL6 mRNA levels of 328 OSCC patients from The Cancer Genome Atlas (TCGA) dataset. The results showed that plasma EGFL6 levels were significantly higher in patients with OSCC than in healthy controls (p < 0.001). Similar results were observed for the TCGA bioinformatics database. Moreover, plasma EGFL6 levels were significantly higher in the patients with advanced T status (p = 0.002), distant metastasis (p = 0.001), and higher TNM stage (p=0.033). In conclusion, our results suggest that plasma level of EGFL6 may be useful to assess disease progression, and especially advanced T status and higher TNM stage in patients with OSCC.