Low-voltage-activated T-type Ca2+ channels.
Low-voltage-activated T-type Ca2+ channels.
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低电压激活的 T 型 Ca2 通道。
DOI：
10.1016/s0165-6147(96)01021-8
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发表时间：
1997
影响因子：
13.8
通讯作者：
E. A. Ertel
中科院分区：
文献类型：
--
作者：
S. Ertel;E. A. Ertel
尽管我们对T通道及其生理作用的了解进展比其他Ca 2+通道要慢，但在为期两天的研讨会上很明显，该领域的兴趣和研究仍然非常强烈。进展受到许多因素的阻碍：电流幅度小，缺乏药理学工具，明显的异质性，以及缺乏克隆通道。尽管如此，许多有趣的作用T通道已被描述，这指向一个一般微妙的调节作用。此外，最近的结果表明，上述障碍可能很快被废除：正在开发具有T通道选择性的新药理学工具（米贝拉地尔和新一代化合物），许多研究小组声称接近克隆T通道。
Although progress in our understanding of T channels and their physiological role has been slower than with other Ca2+channels, it was clear during this two-day workshop that interest and research in the field remain very intense. Advances have been hampered by many factors: small current amplitude, lack of pharmacological tools, apparent heterogeneity, and lack of a cloned channel. Nevertheless, many interesting roles for T channels have been described, which point to a generally subtle modulatory action. Furthermore, recent results suggest that the above barriers might soon be abolished: new pharmacological tools (mibefradil and newer generation compounds) with T-channel selectivity are being developed and many groups claim to be close to cloning a T channel.