[Histopathological comparison of stage A prostatic adenocarcinoma in Japan and the United States].
[Histopathological comparison of stage A prostatic adenocarcinoma in Japan and the United States].
复制标题
日本与美国A期前列腺腺癌的组织病理学比较。
DOI：
10.5980/jpnjurol1989.84.1110
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
M. Harada
中科院分区：
文献类型：
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作者：
K. Uchida;T. Shimazui;M. Ohtani;H. Akaza;K. Koiso;R. Nemoto;M. Harada
对日本的A期前列腺癌(137例)和美国的A期前列腺癌(51例)的病理组织学特征进行了对比分析。所有病例均由一位病理学家(MH)根据日本前列腺癌通用规则(JGRPC)进行分类，按Mostofi-WHO系统进行核分级和Gleason分级。高分化、低核间变、Gleason分级1~2级和组织学评分2~4分的病例，日本病例的发生率明显高于美国病例。在来自美国的病例中，中分化腺癌和2级核间变的比例超过了高分化和1级间变的比例。在来自美国的病例中，Gleason分级为3级的腺癌和组织学评分为6-8级的腺癌也更常见。在分类为A2期的日本病例和来自美国的全部病例中，各组织学分级的分布没有不同。这些结果表明，如果对A期腺癌的亚化采用严格的标准，美国可能会有更多的A期腺癌落入A2期，这可能反映了临床前列腺癌发病率的显著差异。
Histopathological characteristics of stage A prostatic adenocarcinoma from Japan (137 cases) and the United States (51 cases) were comparatively evaluated by retrospective analysis. All cases were examined by one referee pathologist (MH) using classification based on Japanese General Rules for Prostatic Cancer (JGRPC), nuclear grading by Mostofi-WHO system and Gleason grading. The incidences of the cases with well differentiated, low nuclear anaplasia and Gleason grade 1 or 2 on primary and secondary grades as well as histologic score 2-4 were much more higher in the cases from Japan as compared with those from the US. In the cases from the US proportion of the cases with moderately differentiated adenocarcinoma and grade 2 nuclear anaplasia exceeded those with well differentiated and grade 1 anaplasia. Adenocarcinomas with Gleason grade 3 in primary and secondary grade and 6-8 of histologic score were also more frequently observed in the cases from the US. No different distribution of each histologic grade could be obtained among the Japanese cases classified stage A2 and entire cases from the US. These results suggest that much more stage A adenocarcinoma in the US might fall into A2 if strict criteria was applied for subcalssification of stage A, which may reflected in the remarkable difference in the incidence of clinical prostatic carcinoma.
前列腺癌的发病机制特别涉及环境因素。
影响因子：
--
作者：
Bosland,MC
通讯作者：
Bosland,MC