Synthesis and stability of 3-nitro-2-pyridinesulfenyl chloride (NpysCl).
Synthesis and stability of 3-nitro-2-pyridinesulfenyl chloride (NpysCl).
复制标题
3-硝基-2-吡啶硫基氯（NpysCl）的合成和稳定性。
DOI：
10.1111/j.1399-3011.1993.tb00492.x
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Stewart,JM
中科院分区：
文献类型：
--
作者：
Pugh,KC;Gera,L;Stewart,JM
3-硝基-2-吡啶磺酰氯（NpysCl）是合成N-、O-和S-Npys-保护氨基酸的起始原料。描述了NpysCl的两种高效、新颖的合成路线。在各种溶剂中测定NpysCl的稳定性，有和没有碱，以确定最适合合成N-Npys氨基酸的溶剂和碱。还描述了Npys-Ala和Boc-Lys（Npys）叔丁基铵盐的合成。
3‐Nitro‐2‐pyridinesulfenyl chloride (NpysCl) is the starting material for the synthesis ofN‐, O‐andS‐Npys‐protected amino acids. Two efficient, novel synthetic routes to NpysCl are described. The stability of NpysCl was determined in a variety of solvents, with and without base, to determine the most suitable solvent and base for the synthesis ofN‐Npys amino acids. The syntheses of Npys‐Ala and Boc‐Lys(Npys)tert‐butylammonium salt are also described.