Dietary n-3 and n-6 fatty acid intakes and NAFLD: A cross-sectional study in the United States
Dietary n-3 and n-6 fatty acid intakes and NAFLD: A cross-sectional study in the United States
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DOI：
10.6133/apjcn.202103_30(1).0011
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发表时间：
2021-03-01
影响因子：
1.3
通讯作者：
Sun, Yongye
中科院分区：
文献类型：
--
作者：
Cui, Jiajia;Li, Lianghui;Sun, Yongye
背景和目的：多不饱和脂肪酸在非酒精性脂肪性肝病（NAFLD）的发生发展中起关键作用。这项研究检查了美国人群饮食n-3和n-6 PUFA摄入量与NAFLD风险之间的关系。方法和研究设计：这项横断面研究使用了2007-2014年国家健康和营养检查调查（NHANES）的数据。饮食n-3和n-6 PUFA的数据提取通过两个24小时的饮食回忆访谈，饮食n-3和n-6 PUFA的摄入量进行调整的重量。根据美国脂肪肝指数（FLI）值>= 30定义NAFLD。应用多变量logistic回归模型和限制性三次样条模型研究膳食n-3和n-6 PUFA摄入量与NAFLD风险之间的关系。结果：膳食n-3和n-6 PUFA摄入量与NAFLD风险呈负相关。饮食n-3和n-6 PUFA摄入量最高与最低四分位数的NAFLD多变量调整OR（95%CI）分别为0.24（0.17-0.35）和0.18（0.13-0.26）。在按性别和年龄进行的分层分析中，饮食中n-3和n-6 PUFA摄入量与NAFLD风险之间的负相关在男性、女性和45岁以上的年轻人中均显着。剂量反应分析表明，NAFLD风险与膳食n-3和n-6 PUFA摄入量呈非线性相关。结论：在美国成年人中，膳食n-3和n-6 PUFA摄入量与NAFLD风险呈负相关。
Background and Objectives: PUFAs play critical roles in the development of nonalcoholic fatty liver disease (NAFLD). This study examined the associations between dietary n-3 and n-6 PUFA intake and NAFLD risk in a US population. Methods and Study Design: Data from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 was used in this cross-sectional study. Data on dietary n-3 and n-6 PUFAs were extracted through two 24-h dietary recall interviews, and the dietary n-3 and n-6 PUFA intakes were adjusted by weight. NAFLD was defined based on the US fatty liver index (FLI) value >= 30. Multivariable logistic regression models and restricted cubic spline models were applied to investigate the associations between dietary n-3 and n-6 PUFA intakes and NAFLD risk. Results: Dietary n-3 and n-6 PUFA intakes were inversely associated with NAFLD risk. The multivariable-adjusted OR (95% CI) of NAFLD for the highest versus lowest quartile of dietary n-3 and n-6 PUFA intakes was 0.24 (0.17-0.35) and 0.18 (0.13-0.26), respectively. In stratified analyses by sex and age, the negative associations between dietary n-3 and n-6 PUFA intakes and NAFLD risk were significant in men, women, and individuals younger and older than 45 years. Dose-response analyses indicated that NAFLD risk was associated with dietary n-3 and n-6 PUFA intakes in a nonlinear manner. Conclusions: Dietary n-3 and n-6 PUFA intakes were inversely associated with NAFLD risk in US adults.