Distribution of the homeostasis model assessment of insulin resistance in Mexican children and adolescents
Distribution of the homeostasis model assessment of insulin resistance in Mexican children and adolescents
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DOI：
10.1530/eje-11-0844
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发表时间：
2012-02-01
影响因子：
5.8
通讯作者：
Guerrero-Romero, Fernando
中科院分区：
文献类型：
--
作者：
Aradillas-Garcia, Celia;Rodriguez-Moran, Martha;Guerrero-Romero, Fernando
目的：已建议使用胰岛素抵抗稳态模型评估的几个临界点（HOMA-IR；从 2.5 到 4.0 不等）来诊断青少年 IR。在本研究中，我们确定了墨西哥儿童和青少年中 HOMA-IR 的分布。 设计和方法：来自墨西哥中部和北部城市圣路易斯波托西、莱昂、克雷塔罗和杜兰戈的 6132 名儿童和青少年被纳入一项基于人群的横断面研究。符合资格的参与者是表面健康的 6 至 18 岁儿童和青少年。怀孕和存在慢性疾病是排除标准。结果：本研究共纳入 3701 名女孩（60.3%）和 2431 名男孩（39.7%）。在总体人群中，平均体重指数、胰岛素水平和空腹血糖水平分别为21.8G1.3 kg/m 2 、7.1G3.2 mU/ml 和86.2G10.0 mg/dl 。胰岛素和空腹血糖浓度从 6 岁到 12 岁逐渐增加，而在 13 岁到 18 岁人群中浓度趋于稳定。 HOMA-IR的绝对平均值为2.89G0.7。 HOMA-IR随着年龄的增长而逐渐增加，并在13岁时达到平台期。结论：由于胰岛素浓度、血糖水平和HOMA-IR随着年龄的增长而逐渐增加，且与肥胖无关，因此我们的结果表明，儿童IR的评估应基于HOMA-IR的百分位数，而不是基于单一截止点得出的二分值。
Objective: Several cutoff points of the homeostasis model assessment of insulin resistance (HOMA-IR; varying from 2.5 to 4.0) have been suggested for diagnosing IR in youth. In this study, we determined the distribution of the HOMA-IR in Mexican children and adolescents.Design and methods: A total of 6132 children and adolescents from San Luis Potosi, Leo ' n, Queretaro, and Durango, which are cities in central and northern Mexico, were enrolled in a population-based cross-sectional study. Eligible participants were apparently healthy children and adolescents aged 6-18 years. Pregnancy and the presence of chronic illnesses were exclusion criteria.Results: A total of 3701 (60.3%) girls and 2431 (39.7%) boys were included in this study. In the overall population, the mean body mass index, insulin levels, and fasting glucose levels were 21.8G1.3 kg/m 2, 7.1G3.2 mU/ml, and 86.2G10.0 mg/dl respectively. The concentrations of insulin and fasting glucose gradually increased from 6 to 12 years of age, whereas the concentrations tended to plateau in the 13- to 18-year-old population. The absolute mean of the HOMA-IR was 2.89G0.7. The HOMA-IR gradually increased with age and reached a plateau at 13 years of age.Conclusions: Because the insulin concentrations, glucose levels, and HOMA-IR exhibited a gradual increase with age that was not related to obesity, our results suggested that the evaluation of IR in children should be based on percentiles of the HOMA-IR rather than a dichotomous value derived from a single cutoff point.