Association of Primary Biliary Cirrhosis and Rheumatoid Arthritis
Association of Primary Biliary Cirrhosis and Rheumatoid Arthritis
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原发性胆汁性肝硬化与类风湿性关节炎的关联
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
K. Lindor
中科院分区：
文献类型：
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作者：
J. Siegel;H. Luthra;J. Donlinger;P. Angulo;K. Lindor
原发性胆汁性肝硬化（PBC）和类风湿性关节炎（RA）是慢性疾病，虽然病因不确定，但自身免疫特征占主导地位。事实上，这两种情况是多系统疾病，具有多种表现，并不限于其靶器官。已经确定PBC患者可能有肌肉骨骼不适，RA患者可能有肝功能障碍的证据。这两种情况都是相当罕见的，RA被发现在大约1%的人口和PBC被发现在大约20/100，000的妇女和2/100，000的男性。这些不常见的条件发生在同一个病人的可能性是非常罕见和不寻常的。我们已经确定了一个独特的25例患者谁符合疾病定义标准的RA和PBC。这种结合的意识应促使风湿病学家评估PBC与抗线粒体抗体检测异常的肝脏检查的患者，也提高了认识，RA患者的异常肝脏检查并不总是由于药物。
Primary biliary cirrhosis (PBC) and rheumatoid arthritis (RA) are chronic medical conditions in which, although the etiology is uncertain, autoimmune features predominate. These two conditions are, in fact, multisystemic diseases, with a multitude of manifestations that are not limited to their target end organ. It has been well established that patients with PBC may have musculoskeletal complaints and patients with RA may have evidence of hepatic dysfunction. Both of these conditions are fairly rare, with RA being found in approximately 1% of the population and PBC being found in approximately 20/100,000 women and 2/100,000 men.The likelihood of these uncommon conditions occurring in the same patient is very rare and unusual.We have identified a unique group of 25 patients who have met disease-defining criteria for both RA and PBC. Awareness of this combination should prompt rheumatologists to assess for PBC with antimitochondrial antibody testing in patients with abnormal liver tests and also to raise awareness that abnormal liver tests in RA patients are not always due to drugs.
影响因子：
29.4
作者：
Kim, WR;Lindor, KD;Dickson, ER
通讯作者：
Dickson, ER