Regenerative Engineering: Approaches to Limb Regeneration and Other Grand Challenges
Regenerative Engineering: Approaches to Limb Regeneration and Other Grand Challenges
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DOI：
10.1007/s40883-015-0006-z
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发表时间：
2015-12-01
影响因子：
2.6
通讯作者：
Nair, Lakshmi S.
中科院分区：
文献类型：
--
作者：
Laurencin, Cato T.;Nair, Lakshmi S.
再生复杂组织和器官系统的临床重大挑战需要一种跨学科方法的范式转变。再生工程领域提出了一种融合方法，以创建一个再生工具箱，超越个体组织修复，以再生复杂的组织和器官系统。在这里，我们讨论了再生工具箱目前正在开发中，以解决复杂的组织/器官regeneration.Lay SummaryRegenerating受损的组织，而不是修复或更换的大机会是圣杯，以解决器官损伤的临床挑战。与先进的假肢不同，“再生工程”领域旨在完全再生复杂的组织和器官系统，如膝盖或整个肢体。
The clinical grand challenge to regenerate complex tissue and organ systems calls for a paradigm shift that requires a transdisciplinary approach. The field of regenerative engineering puts forward a convergence approach to create a regenerative toolbox to move beyond individual tissue repair to the regeneration of complex tissues and organ systems. Here, we discuss the regenerative tool box currently under development to address grand opportunities in complex tissue/organ regeneration.Lay SummaryRegenerating damaged tissues rather than repairing or replacing is the holy-grail to address the clinical challenge of organ damage. Unlike advanced prosthetics, the field of "Regenerative Engineering" aims to completely regenerate complex tissues and organ systems such as a knee or a whole limb.