Metabolic syndrome as a risk factor for gallstone disease
Metabolic syndrome as a risk factor for gallstone disease
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DOI：
10.3748/wjg.v11.i11.1653
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发表时间：
2005-03-21
影响因子：
4.3
通讯作者：
Uribe, Misael
中科院分区：
文献类型：
--
作者：
Mendez-Sanchez, Nahum;Chavez-Tapia, Norberto C.;Uribe, Misael
目的：建立代谢综合征的存在与胆石病发展之间的关联。方法：我们在墨西哥城一所大学医院的检查室进行了一项横断面研究。我们招募了 245 名受试者，其中 65 名患有胆结石的受试者（36 名女性，29 名男性）和 180 名对照者（79 名女性和 101 名没有胆结石的男性）。测量体重指数、腰围、血压、血浆胰岛素、血清脂质和脂蛋白水平。通过稳态模型评估计算胰岛素抵抗。使用无条件逻辑回归分析（单变量和多变量）来计算与至少三个标准（成人治疗组 III）的存在相关的胆结石疾病的风险。根据年龄和性别调整分析。结果：在 245 名受试者中，40% 的胆石病受试者存在代谢综合征，而对照组为 17.2%，按年龄和性别调整（比值比 (OR) = 2.79；95% CI，1.46-5.33；P = 0.002），代谢综合征的每个组成部分均观察到剂量依赖性效应（OR = 2.36， 95% CI，0.72-7.71；对于代谢综合征的一种成分，P = 0.16，OR = 5.54，95% CI，1.35-22.74；对于代谢综合征的四种成分，P = 0.02。稳态模型评估与胆石疾病显着相关（调整后 OR = 2.25；95% CI，1.08-4.69；P = 0.03）。结论：我们的结论是，就心血管疾病和糖尿病而言，胆石疾病似乎与代谢综合征密切相关。 (C) 2005 The WJG Press 和 Elsevier Inc. 保留所有权利。
AIM: To establish an association between the presence of metabolic syndrome and the development of gallstone disease.METHODS: We carried out a cross-sectional study in a check-up unit in a university hospital in Mexico City. We enrolled 245 subjects, comprising 65 subjects with gallstones (36 women, 29 men) and 180 controls (79 women and 101 men without gallstones). Body mass index, waist circumference, blood pressure, plasma insulin, and serum lipids and lipoproteins levels were measured. Insulin resistance was calculated by homeostasis model assessment. Unconditional logistic regression analysis (univariate and multivariate) was used to calculate the risk of gallstone disease associated with the presence of at least three of the criteria (Adult Treatment Panel III). Analyses were adjusted for age and sex.RESULTS: Among 245 subjects, metabolic syndrome was present in 40% of gallstone disease subjects, compared with 17.2% of the controls, adjusted by age and gender (odds ratio (OR) = 2.79; 95% CI, 1.46-5.33; P = 0.002), a dose-dependent effect was observed with each component of metabolic syndrome (OR = 2.36, 95% CI, 0.72-7.71; P = 0.16 with one component and OR = 5.54, 95% CI, 1.35-22.74; P = 0.02 with four components of metabolic syndrome). Homeostasis model assessment was significantly associated with gallstone disease (adjusted OR = 2.25; 95% CI, 1.08-4.69; P = 0.03).CONCLUSION: We conclude that as for cardiovascular disease and diabetes mellitus, gallstone disease appears to be strongly associated with metabolic syndrome. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.