Soy isoflavone intake and the likelihood of ever becoming a mother: the Adventist Health Study-2.
Soy isoflavone intake and the likelihood of ever becoming a mother: the Adventist Health Study-2.
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DOI：
10.2147/ijwh.s57137
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Fraser GE
中科院分区：
文献类型：
--
作者：
Jacobsen BK;Jaceldo-Siegl K;Knutsen SF;Fan J;Oda K;Fraser GE
由于对植物雌激素摄入与女性生育能力之间的关系知之甚少，我们研究了大豆异黄酮摄入与不孕不育风险之间的关系。对11688名年龄在30-50岁之间的北美复临妇女进行了一项关于生育数据的横断面研究。作为一个群体，这些妇女的特点是素食者比例高（54%），生活方式健康，吸烟和饮酒的流行率非常低。与其他西方人群相比，平均异黄酮摄入量（每天17.9毫克）非常高。只有6%的女性表示没有摄入异黄酮。我们发现，在调整了年龄、婚姻状况和教育水平后，异黄酮摄入量与成为母亲的可能性呈负相关（P=0.05）。在异黄酮摄入量高（≥40毫克/天）的妇女中（占该组妇女的12%），与摄入量低（<10毫克/天）的妇女相比，调整后的终身活产概率降低了约3% （95% CI: 0.7）。没有发现异黄酮的摄入与产次或首次分娩年龄之间的关系。异黄酮摄入量与无妊娠风险之间也存在类似的负相关关系（P=0.03），高异黄酮摄入量（≥40 mg/天）的女性从未怀孕的风险高出13% （95% CI: 2,26）。这些关系主要出现在报告怀孕问题的女性身上。研究结果表明，饮食中摄入大量异黄酮可能对生育能力有重大影响。
As little is known about the possible relationship between the intake of phytoestrogens and female fertility, we investigated the relationship between soy isoflavone intake and the risk of nulliparity and nulligravidity. A cross-sectional study of 11,688 North American Adventist women aged 30–50 years old with data regarding childbearing. These women were, as a group, characterized by a high proportion (54%) of vegetarians and a healthy lifestyle with a very low prevalence of smoking and alcohol use. The mean isoflavone intake (17.9 mg per day) was very high compared to other Western populations. Only 6% of the women indicated no intake of isoflavones. We found, after adjustment for age, marital status, and educational level, an inverse relationship (P=0.05) between isoflavone intake and the likelihood of ever having become a mother. In women with high (≥40 mg/day) isoflavone intake (12% of this group of women), the adjusted lifetime probability of giving birth to a live child was reduced by approximately 3% (95% CI: 0, 7) compared to women with low (<10 mg/day) intake. No relationships were found between the isoflavone intake and parity or age at first delivery in parous women. A similar inverse relationship (P=0.03) was found between the isoflavone intake and the risk of nulligravidity with a 13% (95% CI: 2, 26) higher risk of never have been pregnant in women with high (≥40 mg/day) isoflavone intake. These relationships were found mainly in women who reported problems becoming pregnant. The findings suggest that a high dietary isoflavone intake may have significant impact on fertility.