Variability of HIV-1 RNA before AIDS and highly active antiretroviral therapy.
Variability of HIV-1 RNA before AIDS and highly active antiretroviral therapy.
复制标题
艾滋病和高效抗逆转录病毒治疗之前 HIV-1 RNA 的变异性。
DOI：
10.1097/00002030-200305230-00023
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Muñoz,Alvaro
中科院分区：
文献类型：
--
作者：
Yamashita,TraciE;Modjarrad,Kayvon;Muñoz,Alvaro
1975年，世界卫生组织谴责了商业血浆置换对公众健康的威胁[4]，但国际或地方没有采取措施来规范血浆置换中心的运作或血浆运输。血浆是美国、西欧和日本不断扩张且利润丰厚的血浆分离行业的原材料[3]。这是一个双重问题：首先，付费捐献者在血浆置换中心内受到感染，污染了发达国家分离行业的血浆源。其次，这些产品的接受者，通常是高收入国家的患者，例如 20 世纪 80 年代的血友病患者，通过这种血浆的最终产品而受到感染。这个问题也在当地蔓延，因为这些付费捐献者也会出售全血，用于国内输血，就像墨西哥的情况一样，那里主要是育龄妇女，在短时间内就被非常有效地感染。
The menace that commercial plasmapheresis represented to public health was denounced by WHO in 1975 [4], but no international or local measures were taken to regulate the functioning of plasmapheresis centres or the traffic in plasma. Plasma constituted the raw material for an expanding and highly profitable plasma fractionation industry in the United States, Western Europe and Japan [3].This is a dual problem: in the first place, paid donors get infected within plasmapheresis centres, contaminating the source plasma for the fractionation industries of developed countries. In the second place, recipients of these products, usually patients in high-income countries such as haemophiliacs in the 1980s, become infected through the end-products of this plasma. The problem also extends locally, as these same paid donors will also sell whole blood that will be used for transfusion within the country, as was the case in Mexico, where women predominantly of childbearing age were infected very efficiently and in a short period.