Examination of the nicotine dependence (NICSNP) consortium findings in the Iowa adoption studies population.
Examination of the nicotine dependence (NICSNP) consortium findings in the Iowa adoption studies population.
复制标题
对爱荷华州收养研究人群中尼古丁依赖 (NICSNP) 联盟调查结果的检查。
DOI：
10.1093/ntr/ntn034
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Madden,Pamela
中科院分区：
文献类型：
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作者：
Philibert,RobertA;Todorov,Alexandre;Andersen,Allan;Hollenbeck,Nancy;Gunter,Tracy;Heath,Andrew;Madden,Pamela
IntroductionNicotine dependence results from a complex interplay of genetic and environmental factors. Over the past several years, a large number of studies have been performed to identify distinct gene loci containing genetic vulnerability to nicotine dependence. Two of the most prominent studies were conducted by the Collaborative Study of the Genetics of Nicotine Dependence (NICSNP) Consortium using both candidate gene and high-density association approaches.MethodsWe attempted to confirm and extend the most significant findings from the high-density association study and the candidate gene study using the behavioral and genetic resources of the Iowa Adoption Studies, the largest case–control adoption study of substance use in the United States.ResultsWe found evidence that genetic variation atCHRNA1,CHRNA2,CHRNA7, andCHRNB1alters susceptibility to nicotine dependence, but we did not replicate any of the most significant single nucleotide polymorphism associations from the NICSNP high-density association study.DiscussionFurther examination of the NICSNP findings in other population samples is indicated.
