High magnitude exposure to repetitive head impacts alters female adolescent brain activity for lower extremity motor control.
High magnitude exposure to repetitive head impacts alters female adolescent brain activity for lower extremity motor control.
复制标题
剧烈的重复性头部撞击会改变女性青少年下肢运动控制的大脑活动。
DOI：
10.1016/j.brainres.2024.148785
复制
发表时间：
2024
期刊：
影响因子：
2.9
通讯作者：
Diekfuss,JedA
中科院分区：
文献类型：
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作者：
Zuleger,TaylorM;Slutsky-Ganesh,AlexisB;Grooms,DustinR;Yuan,Weihong;BarberFoss,KimD;Howell,DavidR;Myer,GregoryD;Diekfuss,JedA
青少年运动员的接触和碰撞运动参与引起了人们对累积重复头部撞击（RHIs）对大脑功能的潜在负面影响的担忧。RHI和运动相关脑震荡（SRC）的损害可能会传播到挥之不去的神经肌肉控制。然而，将RHI与改变的运动控制过程联系起来的神经机制仍然未知。本研究的目的是分离与RHI暴露的频率和幅度相关的下肢运动控制任务的神经活动变化。一组15名高中女子足球运动员参加了一项前瞻性纵向研究，并接受了赛季前和赛季后的功能磁共振成像（fMRI）。在功能磁共振成像，运动员完成同时双侧踝关节，膝关节和髋关节屈曲/伸展运动的阻力（双侧腿部压力），以表征与下肢运动控制相关的神经活动。RHI数据被分为20 g-120 g之间的连续类别（由逐渐增大的间隔定义），在fMRI分析中独立建模了撞击次数。结果显示，不同程度暴露于高强度RHI（≥ 90 g- <110 g和≥ 110 g）与双侧腿部按压神经活动的急性变化相关（广泛包括运动、视觉和认知区域;所有p < 0.05 & z > 3.1）。更多地暴露于高强度RHI可能通过适应不良的神经机制损害下肢运动控制。未来的工作是必要的，以扩大这些机制的研究结果，并检查RHI暴露和神经活动之间的联系，因为它涉及到随后的神经肌肉控制缺陷。
Contact and collision sport participation among adolescent athletes has raised concerns about the potential negative effects of cumulative repetitive head impacts (RHIs) on brain function. Impairments from RHIs and sports-related concussions (SRC) may propagate into lingering neuromuscular control. However, the neural mechanisms that link RHIs to altered motor control processes remain unknown. The purpose of this study was to isolate changes in neural activity for a lower extremity motor control task associated with the frequency and magnitude of RHI exposure. A cohort of fifteen high school female soccer players participated in a prospective longitudinal study and underwent pre- and post-season functional magnetic resonance imaging (fMRI). During fMRI, athletes completed simultaneous bilateral ankle, knee, and hip flexion/extension movements against resistance (bilateral leg press) to characterize neural activity associated with lower extremity motor control. RHI data were binned into continuous categories between 20g− 120g(defined by progressively greater intervals),with the number of impacts independently modeled within the fMRI analyses. Results revealed that differential exposure to high magnitude RHIs (≥90g- < 110gand ≥ 110g) was associated with acute changes in neural activity for the bilateral leg press (broadly inclusive of motor, visual, and cognitive regions; all p < 0.05 & z > 3.1). Greater exposure to high magnitude RHIs may impair lower extremity motor control through maladaptive neural mechanisms. Future work is warranted to extend these mechanistic findings and examine the linkages between RHI exposure and neural activity as it relates to subsequent neuromuscular control deficits.