Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 2: Current Management (Publication with Expression of Concern)
Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 2: Current Management (Publication with Expression of Concern)
复制标题
DOI：
10.1093/ecco-jcc/jjx009
复制
发表时间：
2017-07-01
影响因子：
8
通讯作者：
Carbonnel, Franck
中科院分区：
文献类型：
--
作者：
Harbord, Marcus;Eliakim, Rami;Carbonnel, Franck
11.1.溃疡性结肠炎[UC]的治疗策略主要基于疾病的严重程度、分布[直肠炎、左侧、广泛]1和疾病的类型。后者包括复发频率、病程、对以前用药的反应、用药的副作用和肠外表现。发病年龄和病程也是重要因素。重要的是要区分需要住院的重症UC患者和那些可以作为门诊患者进行治疗的轻度或中度活动性疾病的患者。最有效和最广泛使用的识别严重UC的指数仍然是Truelove和Witts的指数。2例血便频率为6次/天、心动过速或体温为37.8℃，或贫血[血红蛋白10.5g/dl]或血沉升高[≥；30 mm/h]的患者患有严重的UC。除了血便频率≥6/天之外，只需要一个额外的标准来定义严重发作。3、4在实际操作中，可以用30 mg/L的C反应蛋白代替血沉。
11.1. General The treatment strategy for ulcerative colitis [UC] is mainly based on the severity, distribution [proctitis, left-sided, extensive] 1 and pattern of disease. The latter includes relapse frequency, disease course, response to previous medications, side effects of medication, and extra-intestinal manifestations. Age at onset, and disease duration are also important factors. It is important to distinguish patients with severe UC necessitating hospital admission from those with mild or moderately active disease who can be managed as outpatients. The best validated and most widely used index for identifying severe UC remains that of Truelove and Witts. 2 Patients with bloody stool frequency≥ 6/day and a tachycardia [> 90 min− 1], or temperature> 37.8 C, or anaemia [haemoglobin< 10.5 g/dl], or an elevated erythrocyte sedimentation rate [ESR][> 30 mm/h] have severe UC. Only one additional criterion in addition to the bloody stool frequency≥ 6/day is needed to define a severe attack. 3, 4 In practice, a C-reactive protein [CRP] of 30 mg/l can be substituted for the ESR.