Asymmetric rotational stroke in mouse node cilia during left-right determination
Asymmetric rotational stroke in mouse node cilia during left-right determination
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DOI：
10.1103/physreve.87.050701
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发表时间：
2013-05-15
影响因子：
2.4
通讯作者：
Hamada, Hiroshi
中科院分区：
文献类型：
--
作者：
Takamatsu, Atsuko;Ishikawa, Takuji;Hamada, Hiroshi
研究了小鼠胚胎中离体单纤毛的旋转运动，该运动在结腔内产生向左的流体流动，在左右决定中起重要作用。向左单向流动是由于纤毛旋转轴向后侧倾斜所致。通过将计算流体力学与实验观察相结合，我们证明了在恒定驱动扭矩下，考虑纤毛倾斜和无滑移的情况下，左冲程比预期的更有效。我们的结果表明，驱动力矩是不对称的。
Rotational movement of isolated single cilia in mice embryo was investigated, which generates leftward fluid flow in the node cavity and plays an important role in left-right determination. The leftward unidirectional flow results from tilting of the rotational axis of the cilium to the posterior side. By combining computational fluid dynamics with experimental observations, we demonstrate that the leftward stroke can be more effective than expected for cases in which cilia tilting alone is considered with the no-slip condition under constant driving torque. Our results suggest that the driving torque is asymmetric.