Erythropoiesis: comparison of in vivo and in vitro amplification.
Erythropoiesis: comparison of in vivo and in vitro amplification.
复制标题
红细胞生成：体内和体外扩增的比较。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
M. Prenant
中科院分区：
文献类型：
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作者：
M. Bessis;C. Mize;M. Prenant
1.扩增被定义为红细胞生成的阶段，包括可识别的红细胞的所有细胞分裂。2.在体内，扩增总是发生在中央组织细胞(红细胞岛)周围。它由四到五个连续的同步分区组成。3.在体外，红系细胞可在不与中枢组织细胞明显结合的情况下完全成熟和扩增。4.讨论了红系造血岛的功能意义和扩增异常与临床红细胞生成障碍的关系。
1. Amplification is defined as the phase of erythropoiesis that includes all cell divisions of the recognizable erythron. 2. In vivo, amplification always takes place surrounding a central histiocyte (erythroblastic island). It is made up of four to five successive synchronous divisions. 3. In vitro, complete maturation and amplification of erythropoietic cells can be obtained without apparent association with a central histiocyte. 4. The functional significance of the 'erythroblastic island' and disorders of amplification are discussed in relation to clinical disorders of erythropoiesis.