The microRNA-17-92 family of microRNA clusters in development and disease.
The microRNA-17-92 family of microRNA clusters in development and disease.
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DOI：
10.1097/ppo.0b013e318258b60a
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
Ventura A
中科院分区：
文献类型：
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作者：
Concepcion CP;Bonetti C;Ventura A
过去十年积累的大量实验证据表明，microRNAs （miRNAs）是动植物基因表达的关键调控因子，在发育、体内平衡和疾病中发挥重要作用。miRNA簇的miR-17~92家族由三个相关的、高度保守的、多顺反子的miRNA基因组成，它们总共编码15个miRNA。在这里，我们讨论了最近的研究表明，这些mirna是脊椎动物发育和体内平衡所必需的。我们还展示了它们的突变或解除管制如何有助于各种人类疾病的发病机制，包括癌症和先天性发育缺陷。最后，我们讨论了目前的证据表明，由这三个集群编码的不同mirna如何在功能上合作，以微调信号传导和发育途径。
Overwhelming experimental evidence accumulated over the past decade indicates that microRNAs (miRNAs) are key regulators of gene expression in animals and plants and play important roles in development, homeostasis and disease. The miR-17~92 family of miRNA clusters is composed of three related, highly conserved, polycistronic miRNA genes that collectively encode for a total of fifteen miRNAs. Here we discuss recent studies demonstrating that these miRNAs are essential for vertebrate development and homeostasis. We also show how their mutation or deregulation contributes to the pathogenesis of a variety of human diseases, including cancer and congenital developmental defects. Finally, we discuss the current evidence suggesting how the different miRNAs encoded by these three clusters can functionally cooperate to fine-tune signaling and developmental pathways.