Iron nanoparticles in the coupling of alkyl halides with aryl Grignard reagents
Iron nanoparticles in the coupling of alkyl halides with aryl Grignard reagents
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DOI：
10.1039/b601014h
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发表时间：
2006-01-01
影响因子：
4.9
通讯作者：
Hird, M
中科院分区：
文献类型：
--
作者：
Bedford, RB;Betham, M;Hird, M
铁纳米颗粒，无论是由 1,6-双（二苯基膦）己烷或聚乙二醇（PEG）原位稳定形成，还是由 PEG 稳定预成型，都是芳基格氏试剂与带有 β-氢的伯烷基卤和仲烷基卤交叉偶联的优异催化剂，并且它们在串联环化/交叉偶联反应中也被证明是有效的。
Iron nanoparticles, either formed in situ stabilized by 1,6-bis(diphenylphosphino) hexane or polyethylene glycol (PEG), or preformed stabilized by PEG, are excellent catalysts for the cross-coupling of aryl Grignard reagents with primary and secondary alkyl halides bearing beta-hydrogens and they also prove effective in a tandem cyclization/cross-coupling reaction.