Association of breast cancer risk with age at first and subsequent births: a study in the population of the Estonian Republic.
Association of breast cancer risk with age at first and subsequent births: a study in the population of the Estonian Republic.
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乳腺癌风险与首次生育和后续生育年龄的关联：一项针对爱沙尼亚共和国人口的研究。
DOI：
10.1093/jnci/69.5.1035
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
E. Hint
中科院分区：
文献类型：
--
作者：
B. Macmahon;M. Purde;D. Cramer;E. Hint
有关生殖史的信息来自于爱沙尼亚共和国塔林和塔尔图肿瘤药房就诊的 362 名城市乳腺癌患者，以及参加同一中心提供的妇科筛查项目的 694 名城市妇女。通过Mantel-Haenszel 和逻辑回归程序对两组进行比较，以估计年龄调整优势比。 20 岁之前第一次生育的女性患乳腺癌的风险不到未生育女性的三分之一。风险随着初产年龄 (AFB) 的增加而增加，但仍低于 1.0（相对于未产妇），即使在最高的 AFB 类别中也是如此。在本研究期间，爱沙尼亚的生育率相对较低，这有利于评估第一胎出生后的影响。经过 AFB 调整后，在该人群中，后续出生似乎比第一次出生具有额外的保护作用。此外，对于只生育两个孩子的女性来说，第二个孩子出生时的年龄是这种影响的决定因素。与未生育女性相比，25岁之前生育的单产女性患乳腺癌的几率为0.62，25岁以下生育孩子的双胎女性患乳腺癌的几率为0.18。在该人群中，哺乳期和初潮都不是乳腺癌的危险因素。
Information on reproductive history was obtained from 362 urban breast cancer patients attending the oncological dispensaries at Tallinn and Tartu, Estonian Republic, and from 694 urban women participating in gynecologic screening programs offered by the same centers. The 2 groups were compared by means of Mantel-Haenszel and logistic regression procedures to estimate age-adjusted odds ratios. Women whose first birth occurred before 20 years of age had a breast cancer risk less than one-third the risk of nulliparous women. Risk increased with increase in age at first birth (AFB) but remained below 1.0 (relative to nulliparae), even in the highest AFB categories. The fertility rate in Estonia during the period of this study was relatively low, which facilitated an evaluation of the effect of births subsequent to the first. After adjustment for AFB, it appeared that in this population subsequent births had a protective effect additional to that conferred by the first birth. Moreover, for women who had only 2 children, the age at the time of birth of the second child was a determinant of that effect. Compared to nulliparous women, the breast cancer odds ratio for uniparous women who had their child before age 25 was 0.62, and the ratio for duoparous women who had both their children under that age was 0.18. Neither lactation nor menarche was a risk factor for breast cancer in this pouplation.