Reaching the limit of the oculomotor plant: 3D kinematics after abducens nerve stimulation during the torsional vestibulo-ocular reflex.
Reaching the limit of the oculomotor plant: 3D kinematics after abducens nerve stimulation during the torsional vestibulo-ocular reflex.
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DOI：
10.1523/jneurosci.2595-12.2012
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发表时间：
2012-09-19
期刊：
影响因子：
--
通讯作者：
Angelaki DE
中科院分区：
文献类型：
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作者：
Klier EM;Meng H;Angelaki DE
越来越多的证据表明，动眼植物能够实现三维运动学的各个方面，例如Listing定律和半角规则。但这些研究仅在静态条件下或通常遵循这些规则的运动（例如眼跳和追踪）下检查眼睛。在这里，我们测试动眼植物根据非半角行为的需要重新排列自身的能力。三只猴子（Macaca mulatta）坐在围绕鼻枕轴正弦旋转的运动平台上，沿着正中矢状面固定五个垂直移位的目标。这激活了扭转、旋转前庭眼反射，表现出零角度或负角度规则（取决于视觉刺激）。在随机正弦周期中，我们刺激外展神经并观察由此产生的眼球运动。如果植物重新排列自身以实现这种非半角行为，那么刺激应该会揭示这种行为。另一方面，如果植物只能进行半角行为，那么刺激应该揭示半角规则。我们发现后者是正确的，因此可能需要额外的神经信号来实现非半角行为。
Accumulating evidence shows that the oculomotor plant is capable of implementing aspects of three-dimensional kinematics such as Listing's law and the half-angle rule. But these studies have only examined the eye under static conditions or with movements that normally obey these rules (e.g., saccades and pursuit). Here we test the capability of the oculomotor plant to rearrange itself as necessary for non-half-angle behavior. Three monkeys (Macaca mulatta) fixated five vertically displaced targets along the midsagittal plane while sitting on a motion platform that rotated sinusoidally about the naso-occipital axis. This activated the torsional, rotational vestibuloocular reflex, which exhibits a zero-angle or negative-angle rule (depending on the visual stimulus). On random sinusoidal cycles, we stimulated the abducens nerve and observed the resultant eye movements. If the plant has rearranged itself to implement this non-half-angle behavior, then stimulation should reveal this behavior. On the other hand, if the plant is only capable of half-angle behavior, then stimulation should reveal a half-angle rule. We find the latter to be true and therefore additional neural signals are likely necessary to implement non-half-angle behavior.