Identification of natural compounds tubercidin and lycorine HCl against small-cell lung cancer and BCAT1 as a therapeutic target.
Identification of natural compounds tubercidin and lycorine HCl against small-cell lung cancer and BCAT1 as a therapeutic target.
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DOI：
10.1111/jcmm.17246
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发表时间：
2022-05
影响因子：
5.3
通讯作者：
Qin, Zhiqiang
中科院分区：
文献类型：
--
作者：
Chen, Jungang;Barrett, Lindsey;Lin, Zhen;Kendrick, Samantha;Mu, Shengyu;Dai, Lu;Qin, Zhiqiang
虽然小细胞肺癌（SCLC）占肺癌病例的一小部分（约15%），但SCLC患者的预后很差，未经治疗的平均总生存期为几个月。目前的治疗方法包括疗效最低的标准化疗和一种新开发的免疫疗法，迄今为止，这种疗法对有限数量的患者有益。在目前的研究中，我们筛选了一个天然产物库，并确定了5种天然化合物，特别是结核素和石蒜碱HCl，在体外和体内显示出突出的抗SCLC活性。随后的RNA测序和功能验证分析揭示了这些新化合物的抗SCLC机制，并进一步确定了新的细胞因子，如BCAT1，作为SCLC患者具有临床意义的潜在治疗靶点。总之，我们的研究为对抗这种侵袭性肺癌提供了有希望的新方向。
Although small‐cell lung cancer (SCLC) accounts for a small fraction of lung cancer cases (~15%), the prognosis of patients with SCLC is poor with an average overall survival period of a few months without treatment. Current treatments include standard chemotherapy, which has minimal efficacy and a newly developed immunotherapy that thus far, benefits a limited number of patients. In the current study, we screened a natural product library and identified 5 natural compounds, in particular tubercidin and lycorine HCl, that display prominent anti‐SCLC activities in vitro and in vivo. Subsequent RNA‐sequencing and functional validation assays revealed the anti‐SCLC mechanisms of these new compounds, and further identified new cellular factors such as BCAT1 as a potential therapeutic target with clinical implication in SCLC patients. Taken together, our study provides promising new directions for fighting this aggressive lung cancer.
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DOI：
10.1038/s41572-020-00235-0
发表时间：
2021-01-14
期刊：
Nature reviews. Disease primers
影响因子：
--
作者：
Rudin CM;Brambilla E;Faivre-Finn C;Sage J
通讯作者：
Sage J
影响因子：
4.6
作者：
Bankhead P;Loughrey MB;Fernández JA;Dombrowski Y;McArt DG;Dunne PD;McQuaid S;Gray RT;Murray LJ;Coleman HG;James JA;Salto-Tellez M;Hamilton PW
通讯作者：
Hamilton PW
影响因子：
64.8
作者：
Hattori A;Tsunoda M;Konuma T;Kobayashi M;Nagy T;Glushka J;Tayyari F;McSkimming D;Kannan N;Tojo A;Edison AS;Ito T
通讯作者：
Ito T
影响因子：
37.3
作者：
Zhou W;Feng X;Ren C;Jiang X;Liu W;Huang W;Liu Z;Li Z;Zeng L;Wang L;Zhu B;Shi J;Liu J;Zhang C;Liu Y;Yao K
通讯作者：
Yao K
影响因子：
3.7
作者：
Chen, Jungang;Del Valle, Luis;Qin, Zhiqiang
通讯作者：
Qin, Zhiqiang