Effects of flavonoid-containing beverages and EGCG on endothelial function
Effects of flavonoid-containing beverages and EGCG on endothelial function
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DOI：
10.1080/07315724.2007.10719625
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发表时间：
2007-08-01
影响因子：
3.5
通讯作者：
Vita, Joseph A.
中科院分区：
文献类型：
--
作者：
Shenouda, Sherene M.;Vita, Joseph A.
血管内皮细胞的缺失导致动脉粥样硬化从病变发展到临床心血管疾病事件的所有阶段。公认的危险因素，包括糖尿病、高血压、血脂异常、吸烟和久坐的生活方式与内皮功能障碍有关。各种药物和行为干预已被证明可以逆转心血管疾病患者的内皮功能障碍。大量的流行病学研究表明，饮食因素，包括增加含黄酮类化合物的食物和饮料的摄入，可以降低心血管风险，最近的研究表明，这类饮料对内皮功能有有利的影响。这些研究引起了人们对开发膳食补充剂或药物的兴趣，这些膳食补充剂或药物将允许更方便和更高剂量的类黄酮给药，并可能被证明对预防或治疗心血管疾病有用。在本文中，我们将审查内皮功能障碍的动脉粥样硬化的发病机制和临床表现的贡献和最近的数据连接类黄酮和表没食子儿茶素没食子酸酯消费，以改善内皮功能和降低心血管风险。
Abnormalities of the vascular endothelium contribute to all stages of atherosclerosis from lesion development to clinical cardiovascular disease events. Recognized risk factors, including diabetes mellitus, hypertension, dyslipidemia, cigarette smoking, and sedentary lifestyle are associated with endothelial dysfunction. A variety of pharmacological and behavioral interventions have been shown to reverse endothelial dysfunction in patients with cardiovascular disease. A large number of epidemiological studies suggest that dietary factors, including increased intake of flavonoid-containing foods and beverages, reduce cardiovascular risk, and recent studies have shown that such beverages have favorable effects on endothelial function. These studies have engendered interest in the development of dietary supplements or drugs that would allow for more convenient and higher dose administration of flavonoids and might prove useful for prevention or treatment of cardiovascular disease. In this paper, we will review the contribution of endothelial dysfunction to the pathogenesis and clinical expression of atherosclerosis and recent data linking flavonoid and EGCG consumption to improved endothelial function and reduced cardiovascular risk.