A ruthenium(II) complex with a C-2-symmetric diphosphine/diamine tetradentate ligand for asymmetric transfer hydrogenation of aromatic ketones
A ruthenium(II) complex with a C-2-symmetric diphosphine/diamine tetradentate ligand for asymmetric transfer hydrogenation of aromatic ketones
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DOI：
10.1021/om950833b
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发表时间：
1996-02-20
期刊：
影响因子：
2.8
通讯作者：
Noyori, R
中科院分区：
文献类型：
--
作者：
Gao, JX;Ikariya, T;Noyori, R
本文合成了结构相似的N，N '-双[邻-（二苯基膦基）苄叉]环己烷-1，2-二胺和N，N'-双[邻-（二苯基膦基）苄叉]环己烷-1，2-二胺的反式-（RuCl_2）-Cl-II配合物，并测定了它们的分子结构。C-2-对称的二膦/二胺基Ru配合物在苯乙酮在0.1 M 2-丙醇溶液中的不对称转移氢化中充当优异的催化剂前体，在45 ℃下7 h后以97%ee和93%产率产生2-苯基乙醇。这种转移氢化的特征在于在这些条件下的低可逆性。
The trans-(RuCl2)-Cl-II complexes with structurally similar N,N'-bis[o-(diphenylphosphino)benzylidene]cyclohexane-1,2-diamine and N,N'-bis[o-(diphenylphosphino)-benzyl]cyclohexane-1,2-diamine ligands have been synthesized, and their molecular structures have been determined. The C-2-symmetric diphosphine/diamine-based Ru complex acts as an excellent catalyst precursor in asymmetric transfer hydrogenation of acetophenone in a 0.1 M 2-propanol solution, leading to 2-phenylethanol in 97% ee and in 93% yield after 7 h at 45 degrees C. This transfer hydrogenation is characterized by low reversibility under these conditions.