The central executioners of apoptosis: caspases or mitochondria?
The central executioners of apoptosis: caspases or mitochondria?
复制标题
DOI：
10.1016/s0962-8924(98)01273-2
复制
发表时间：
1998-07-01
影响因子：
19
通讯作者：
Kroemer, G
中科院分区：
文献类型：
--
作者：
Green, D;Kroemer, G
细胞凋亡是一种细胞死亡类型，其形态学外观依赖于半胱氨酸蛋白酶家族半胱氨酸蛋白酶的激活。最近，已经清楚的是，半胱天冬酶的抑制并不总是防止不可逆的细胞功能的丧失，尽管它确实防止了细胞凋亡形态的获得。线粒体膜结构和功能的改变可以以半胱天冬酶非依赖性方式发生，并且比半胱天冬酶激活对细胞死亡具有更高的预测价值。在这里，道格拉斯绿色和指南Kroemer认为，半胱天冬酶可能有一个双重功能的凋亡过程中：第一，作为信号转导分子，作为兼性诱导线粒体膜的变化，第二，作为加工酶，协调凋亡表型。他们提出了一种启动凋亡的模型，其中线粒体和半胱天冬酶参与相互激活的自放大途径。
Apoptosis is a type of cell death whose morphological appearance relies on the activation of caspase-family cysteine proteases. Recently, it has become clear that inhibition of caspases does not always prevent irreversible loss of cellular function, although if does prevent the acquisition of apoptotic morphology. Alterations in mitochondrial membrane structure ann function can occur in a caspase-independent fashion and have a higher predictive value for cell death than caspase activation. Here, Douglas Green and Guide Kroemer argue that caspases might have a dual function in the apoptotic process: first, as signal-transduction molecules that act as facultative induces of mitochondrial membrane changes, and, second, as processing enzymes that orchestrate the apoptotic phenotype. They propose a model for initiation of apoptosis in which mitochondria ann caspases engage in a self-amplifying pathway of mutual activation.