Refined Multiscale Entropy: Application to 24-h Holter Recordings of Heart Period Variability in Healthy and Aortic Stenosis Subjects
Refined Multiscale Entropy: Application to 24-h Holter Recordings of Heart Period Variability in Healthy and Aortic Stenosis Subjects
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DOI：
10.1109/tbme.2009.2021986
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发表时间：
2009-09-01
影响因子：
4.6
通讯作者：
Caminal, Pere
中科院分区：
文献类型：
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作者：
Fernando Valencia, Jose;Porta, Alberto;Caminal, Pere
多尺度熵(MSE)被用来表征复杂性作为时间尺度因子tau的函数。尽管该技术得到了广泛的应用，但它存在两个局限性：1)由于粗粒化过程而导致的人为MSE降低；2)由于用于消除快速时间尺度的次优过程而引入的虚假MSE振荡。我们提出了一种改进的均方误差(RMSE)，并将其应用于模拟和从健康组和主动脉狭窄(AS)组获得的24小时Holter心率变异性(HRV)记录。研究表明，与消除快速时间尺度相关的细化在短尺度(跨越短期HRV振荡范围)时更有帮助，而与粗粒化过程相关的细化在大尺度上更有用。在健康受试者中，白天的RMSE在短尺度(即tau=1-2)时小于夜间，而在长尺度(即tau=4-20)时大于夜间。在AS种群中，无论是在短时间尺度上还是在长时间尺度上(即tau=1-11)，白天的RMSE都小于夜间。在白天(即tau=2~9)和夜间(即tau=2)，健康组的RMSE均大于AS组。RMSE克服了MSE的两个局限性，证实了通过观察复杂性作为时间尺度的函数可以得到的互补信息。
Multiscale entropy (MSE) was proposed to characterize complexity as a function of the time-scale factor tau. Despite its broad use, this technique suffers from two limitations: 1) the artificial MSE reduction due to the coarse graining procedure and 2) the introduction of spurious MSE oscillations due to the suboptimal procedure for the elimination of the fast temporal scales. We propose a refined MSE (RMSE), and we apply it to simulations and to 24-h Holter recordings of heart rate variability (HRV) obtained from healthy and aortic stenosis (AS) groups. The study showed that the refinement relevant to the elimination of the fast temporal scales was more helpful at short scales (spanning the range of short-term HRV oscillations), while that relevant to the procedure of coarse graining was more useful at large scales. In healthy subjects, during daytime, RMSE was smaller at short scales (i.e., tau = 1-2) and larger at longer scales (i.e., tau = 4-20) than during night-time. In AS population, RMSE was smaller during daytime both at short and long time scales (i.e., tau = 1-11) than during nighttime. RMSE was larger in healthy group than in AS population during both daytime (i.e., tau = 2-9) and nighttime (i.e., tau = 2). RMSE overcomes two limitations of MSE and confirms the complementary information that can be derived by observing complexity as a function of the temporal scale.