Smoking timing, genetic susceptibility and the risk of incident type 2 diabetes: A cohort study from the UK Biobank.
Smoking timing, genetic susceptibility and the risk of incident type 2 diabetes: A cohort study from the UK Biobank.
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吸烟时机、遗传易感性和 2 型糖尿病发生风险：英国生物银行的一项队列研究。
DOI：
10.1111/dom.15603
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Qi,Lu
中科院分区：
文献类型：
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作者：
Hu,Ying;Li,Xiang;Wang,Xuan;Ma,Hao;Zhou,Jian;Tang,Rui;Kou,Minghao;Heianza,Yoriko;Liang,Zhaoxia;Qi,Lu
目的前瞻性评价吸烟时间与2型糖尿病（T2D）发病风险的关系，并探讨吸烟量或遗传易感性是否会改变两者之间的关系。材料和方法纳入了来自英国生物银行（UK Biobank）的294 815名非糖尿病参与者，包括不吸烟者和吸烟者，他们从醒来到吸第一支烟的时间数据。采用Cox比例风险模型评估吸烟时间与T2D发生风险之间的关系。结果在12年的中位随访期间，共记录了9937例T2D病例。与不吸烟者相比，从醒来到吸第一支烟的时间越短，发生T2D的风险越高（趋势p < 0.001）。在完全调整模型中，吸烟时间与吸烟时间相关的风险比（hr）（95%置信区间）分别为：吸烟时间超过2小时1.46（1.17-1.81）、吸烟时间1-2小时1.51（1.21-1.87）、吸烟时间30-60分钟1.58（1.34-1.85）、吸烟时间5 - 15分钟1.86（1.57-2.21）、吸烟时间小于5分钟2.01（1.60-2.54）。我们发现，即使在轻度吸烟者中，从醒来到吸第一支烟时间最短的人患T2D的风险也高出105%，HR为2.05(1.52-2.76)，与重度吸烟者相当。T2D的遗传风险评分并没有改变这种关联（P‐相互作用= 0.51）。结论从醒来到吸第一支烟的时间越短，发生T2D的风险越高。
AimTo prospectively assess the association of smoking timing with the risk of type 2 diabetes(T2D) and examine whether smoking amount or genetic susceptibility might modify the relationship.Materials and MethodsA total of 294 815 participants without diabetes from the UK Biobank, including non‐smokers and smokers with data on the time from waking to first cigarette, were included. Cox proportional hazards models were used to evaluate the association between smoking timing and the risk of incident T2D.ResultsDuring a median follow‐up time of 12 years, a total of 9937 incident cases of T2D were documented. Compared with non‐smokers, a shorter time from waking to first cigarette was significantly associated with a higher risk of incident T2D (Pfor trend < .001). In the fully adjusted model, the hazard ratios (HRs) (95% confidence interval) associated with smoking timing were 1.46 (1.17–1.81) for more than 2 hours, 1.51 (1.21–1.87) for 1–2 hours, 1.58 (1.34–1.85) for 30–60 minutes, 1.86 (1.57–2.21) for 5–15 minutes and 2.01 (1.60–2.54) for less than 5 minutes. We found that even among those who reported being light smokers, those with the shortest time from waking to first cigarette had a 105% higher risk of T2D with an HR of 2.05 (1.52–2.76), which was comparable with heavy smokers. The genetic risk score for T2D did not modify this association (P‐interaction = .51).ConclusionsOur findings indicate that shorter time from waking to first cigarette is significantly associated with a higher risk of incident T2D.