Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France
Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France
复制标题
DOI：
10.1128/aac.00638-08
复制
发表时间：
2008-10-01
影响因子：
4.9
通讯作者：
Nordmann, Patrice
中科院分区：
文献类型：
--
作者：
Cattoir, Vincent;Poirel, Laurent;Nordmann, Patrice
对121株产超广谱β-内酰胺酶肠杆菌临床分离株进行qepA基因筛查。鉴定了一株产生推定泵QepA 2的CTX-M-15阳性大肠埃希菌分离株（0.8%）。该qepA 2基因位于一个90 kb的可移动质粒上，该质粒可降低对亲水性氟喹诺酮类药物的敏感性。
One hundred twenty-one extended-spectrum beta-lactamse-producing enterobacterial clinical isolates were screened for the qepA gene. A single CTX-M-15-positive Escherichia coli isolate (0.8%) that produced the putative pump QepA2 was identified. This qepA2 gene was located onto a 90-kb mobilizable plasmid that conferred reduced susceptibility to hydrophilic fluoroquinolones.