Hemodynamic Analysis of Microcirculation in Malaria Infection
Hemodynamic Analysis of Microcirculation in Malaria Infection
复制标题
DOI：
10.1007/s10439-009-9641-1
复制
发表时间：
2009-04-01
影响因子：
3.8
通讯作者：
Yamaguchi, Takami
中科院分区：
文献类型：
--
作者：
Kondo, Hitoshi;Imai, Yohsuke;Yamaguchi, Takami
感染疟疾的红细胞(IRBCs)表现出不同的机械性能变化。IRBCs失去其变形性，并发展出细胞黏附和玫瑰花环的特性。为了阐明这些变化如何促进微血管闭塞，我们需要关于疟疾感染中血流动力学的定性和定量信息，包括IRBCs、健康RBC和内皮细胞之间的相互作用。基于流体力学守恒定律，我们建立了带IRBCs的血液流动的数值模型。IRBCs的变形性和粘附性可以用符合胡克定律的弹簧来简单地模拟。我们的模型能够表达IRBCs的基本行为，包括由于与内皮细胞的细胞黏附作用而产生的滚动运动以及与健康RBC的复杂相互作用。我们证实，这些类型的相互作用显著增加了流动阻力，特别是当旋钮形成时。
Malaria-infected red blood cells (IRBCs) show various changes in mechanical properties. IRBCs lose their deformability and develop properties of cytoadherence and rosetting. To clarify how these changes advance microvascular occlusion, we need qualitative and quantitative information on hemodynamics in malaria infection, including the interaction among IRBCs, healthy RBCs, and endothelial cells. We developed a numerical model of blood flow with IRBCs based on conservation laws of fluid dynamics. The deformability and adhesive property of IRBCs were simply modeled using springs governed by Hook's law. Our model could express the basic behavior of IRBCs, including the rolling motion due to cytoadhesive interaction with endothelial cells and complex interaction with healthy RBCs. We confirmed that these types of interactions significantly increase the flow resistance, particularly when knobs develop.