Elevated level of the proinflammatory chemokine, RANTES/CCL5, in the periaqueductal grey causes hyperalgesia in rats
Elevated level of the proinflammatory chemokine, RANTES/CCL5, in the periaqueductal grey causes hyperalgesia in rats
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DOI：
10.1016/j.ejphar.2008.07.009
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发表时间：
2008-09-11
影响因子：
5
通讯作者：
Adler, Martin W.
中科院分区：
文献类型：
--
作者：
Benamar, Khalid;Geller, Ellen B.;Adler, Martin W.
目前的数据提供了第一个体内证据，表明促炎趋化因子，调节正常 T 细胞表达和分泌的激活 (RANTES/CCL.5) 直接显微注射到大鼠的导水管周围灰质中，诱导痛觉过敏，导水管周围灰质是处理疼痛信号的关键大脑区域，也是许多镇痛化合物的主要作用部位。用针对 RANTES/CCL5 的抗体进行预处理可防止痛觉过敏反应，表明 RANTES/CCL5 能够干扰导水管周围灰质水平的痛觉过敏控制，并表明趋化因子阻滞剂可能具有镇痛特性。由 Elsevier B.V. 出版
The present data provide the first in vivo evidence that the proinflammatory chemokine, Regulated on Activation Normal Tcell Expressed and Secreted (RANTES/CCL.5) microinjected directly into the periaqueductal grey in rats, a brain region critical to the processing of pain signals, and a primary site of action of many analgesic compounds, induced hyperalgesia. Pretreatment with antibodies against RANTES/CCL5 prevented the hyperalgesic response, indicating that RANTES/CCL5 is able to interfere with the control of hyperalgesia at the level of the periaqueductal grey and suggesting that chemokine blockers could have analgesic properties. Published by Elsevier B.V.