Gene conversion drives GC content evolution in mammalian histones
Gene conversion drives GC content evolution in mammalian histones
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DOI：
10.1016/s0168-9525(02)00002-1
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发表时间：
2003-02-01
影响因子：
11.4
通讯作者：
Galtier, N
中科院分区：
文献类型：
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作者：
Galtier, N
为了研究基因转换对 DNA 碱基组成的进化影响，我分析了来自人类和小鼠的组蛋白旁系同源基因的详尽数据集。我表明，属于非常相似序列的亚家族（可能正在经历基因转换）的那些基因拷贝比独特的基因拷贝（可能没有经历基因转换）具有更高的 GC 含量。因此，基因转换似乎是一个有偏差的过程，往往会增加 DNA GC 含量，这一结论对脊椎动物等容线的进化具有影响。
To examine the evolutionary influence of gene conversion on DNA base composition, I analysed an exhaustive dataset of histone paralogous genes from human and mouse. I show that those gene copies that belong to subfamilies of very similar sequences (presumably undergoing gene conversion) have a higher GC content than unique gene copies (presumably not undergoing gene conversion). Thus, it seems that gene conversion is a biased process that tends to increase the DNA GC content, a conclusion that has implications for the evolution of isochores in vertebrates.