The long road to immunotherapy for childhood rhabdomyosarcoma.
The long road to immunotherapy for childhood rhabdomyosarcoma.
复制标题
儿童横纹肌肉瘤免疫治疗的漫长道路。
DOI：
10.1002/pbc.23136
复制
发表时间：
2011
影响因子：
3.2
通讯作者：
Keller,Charles
中科院分区：
文献类型：
--
作者：
Huang,Elaine;Rubin,BrianP;Keller,Charles
While anti-cancer responses in host immunity have been identified, this baseline immune surveillance has been inadequate to prevent cancer in 1.5 million individuals in the US each year and many fold more around the globe. The immune modulations caused by cytotoxic chemotherapies are varied and understanding the resulting interactions of the host against cancer will be critical for applying additional immunotherapies to patients. In the case of pediatric cancers, any approach that has the potential for reducing exposure to cytotoxic chemotherapy or radiation during childhood development is worth investigating.Immune responses are divided into innate and adaptive immunity. Innate immunity provides a general response that physically targets microorganisms in order to remove them from the host. Adaptive immunity utilizes a complex set of interactions that allows the immune system to selectively target affected cells by examining them for disease. In the case of cancer, both types of immunity have roles to play but the cytolytic activity of the adaptive response may have the most potential for manipulation. Once an antigen presenting cell (APC) is primed, effector cells are expanded, which then seek out and destroy cells bearing that identifying fragment. Because cancers arise from host tissue, identification of tumor antigens can be difficult and as a result, harnessing the adaptive immune response can be challenging.
