Materno-fetal immunoglobulin transfer and passive immunity during the first trimester of human pregnancy
Materno-fetal immunoglobulin transfer and passive immunity during the first trimester of human pregnancy
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DOI：
10.1093/oxfordjournals.humrep.a135906
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发表时间：
1995-12-01
影响因子：
6.1
通讯作者：
Campbell, S
中科院分区：
文献类型：
--
作者：
Jauniaux, E;Jurkovic, D;Campbell, S
免疫从母亲到妊娠早期胎儿的被动转移特别令人感兴趣，因为据报道先天性感染导致严重胎儿后遗症的发生率很高，我们检查了母体血清、体腔液和羊水中免疫球蛋白 (Ig) 和补体浓度之间的关系，在 34 名正常人中测量了 Ig 分数 G (IgG)、A (IgA) 和 M (IgM) 以及补体因子 3 (C3) 和 4 (C4)。妊娠6至12周之间，还对同一研究组的21个匹配样本测量了弓形虫、巨细胞病毒（CMV）和风疹的特异性抗体浓度，在所有体腔液样本中均检测到了IgG和IgA浓度，而仅在两个羊水中检测到了IgG，体腔液中的IgG和IgA浓度分别比对照组低28倍和128倍母体血清并可能反映胎儿血清浓度。孕龄与体腔 IgG (P = 0.001) 和 IgA (P = 0.014) 浓度之间存在显着正线性相关，体腔液和母体血清中的免疫球蛋白浓度之间没有明显关联，表明随着妊娠的进展，跨胎盘的主动转运增加，体腔或羊水中未检测到 IgM、C3 和 C4，在 13 例中发现了特异性抗体。 63 份体腔液样本和 63 份母体血清样本中的 32 份，仅当它们存在于母体血清中时，才在体腔液中发现它们。这些结果表明，母体 IgG 和 IgA 早在妊娠第 6 周就有可能被胚胎利用。体腔液中 IgG 部分的存在，包括通过胎盘转移的总的和感染因子特异性的，表明它们可能对妊娠早期的先天性感染提供有限的保护。
Passive transfer of immunity from the mother to the first trimester fetus is of particular interest because of the reported high incidence of serious fetal sequelae due to congenital infection, We have examined the relationship between maternal serum, coelomic fluid and amniotic fluid concentrations of immunoglobulin (Ig) and complement, Ig fractions G (IgG), A (IgA), and M (IgM) and complement factors 3 (C3) and 4 (C4) were measured in 34 normal pregnancies between 6 and 12 weeks of gestation, The concentrations of specific antibodies for Toxoplasma gondii, cytomegalovirus (CMV) and rubella were also measured on 21 matched samples from the same study group, IgG and IgA concentrations were detected in all coelomic fluid samples whereas IgG was only measurable in two amniotic fluid samples,IgG and IgA concentrations were respectively 28 and 128 times lower in coelomic fluid than in maternal serum and probably reflect fetal serum concentrations. Significant positive linear correlations were found between gestational age and the coelomic concentrations of IgG (P = 0.001) and IgA (P = 0.014), There was no obvious association between immunoglobulin concentrations in coelomic fluid and maternal serum suggesting increasing active transport across the placenta with advancing gestation, IgM, C3 and C4 were not detected in coelomic or amniotic fluid samples, Specific antibodies were found in 13 out of 63 samples of coelomic fluid and in 32 out of 63 samples of maternal serum, They were found in coelomic fluid only if they were present in maternal serum, These results suggest that maternal IgG and IgA are potentially available to the embryo as early as the 6th week of gestation, The presence in the coelomic fluid of the IgG fraction, both total and infectious agent-specific transferred via the placenta, indicates that they may provide limited protection against congenital infection in the first trimester.