Vitreous Levels of Interleukin-6 and Vascular Endothelial Growth Factor in Macular Edema with Central Retinal Vein Occlusion
Vitreous Levels of Interleukin-6 and Vascular Endothelial Growth Factor in Macular Edema with Central Retinal Vein Occlusion
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DOI：
10.1016/j.ophtha.2008.09.034
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发表时间：
2009-01-01
期刊：
影响因子：
13.7
通讯作者：
Hori, Sadao
中科院分区：
文献类型：
--
作者：
Noma, Hidetaka;Funatsu, Hideharu;Hori, Sadao
Objective: To investigate whether interleukin (IL)-6 or vascular endothelial growth factor (VEGF) influences macular edema in patients with central retinal vein occlusion (CRVO).Design: Retrospective case-control study.Participants: Twenty-seven patients who had macular edema with CRVO and 16 patients with nonischemic ocular diseases (control group).Methods: Retinal ischemia was evaluated by measuring the area of capillary nonperfusion using fluorescein angiography and the public domain Scion Image program, and macular edema was examined by optical coherence tomography. Vitreous fluid samples were obtained at pars plana vitrectomy. VEGF and IL-6 levels in vitreous fluid and plasma were determined with enzyme-linked immunosorbent assay kits.Main Outcome Measures: Vitreous fluid levels of IL-6 and VEGF.Results: The vitreous fluid levels of VEGF (median: 435 pg/ml) and IL-6 (median: 51.2 pg/ml) were significantly higher in the patients with CRVO than in the control group (median: 62.4 pg/ml and 1.07 pg/ml, respectively; P = 0.0046 and P
